Intraperitoneal and Appendiceal Malignancies

Stromal COL12A1 defines a pro-invasive extracellular matrix niche in appendiceal mucinous neoplasms and pseudomyxoma peritonei

This study identifies stromal COL12A1 as a key component of the extracellular matrix niche that supports invasion in appendiceal mucinous neoplasms and pseudomyxoma peritonei.

KRAS inhibition is an effective therapy for appendiceal adenocarcinoma

This study evaluates KRAS inhibitors in appendiceal adenocarcinoma models and patients, showing efficacy in reducing tumor growth and suggesting potential resistance mechanisms.

Transcriptomic profiling of a novel gastric implantation model identifies mechanisms and pathways that drive implantation into explanted human peritoneum

The paper develops a human peritoneal explant model to study gastric cancer implantation, identifies key genes like ADAM12, and shows their role in peritoneal metastasis.

Enhancing HIPEC for Ovarian Cancer using Adjunctive Biomaterials

This paper introduces CO-GEMs as a multifunctional adjunct to HIPEC, improving efficacy, preventing adhesions, and reducing nephrotoxicity in ovarian cancer models.

Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer

The paper develops patient-derived organoids and mouse models of appendiceal cancer to identify phenotypic changes and drug targets in peritoneal metastasis.

Integrated characterization of cell types, states and molecular programs in disseminated appendiceal neoplasms

This study uses scRNA-seq to identify cell types and molecular programs in appendiceal neoplasms, revealing cancer-specific cell states and tumor microenvironment interactions.