Leprosy Research and Treatment

Shared and distinct immunometabolic states link to divergent pathology in cutaneous mycobacterial infections

This study identifies shared and distinct innate immune programs in cutaneous mycobacterial infections and links them to divergent pathological outcomes through metabolic interactions.

A zebrafish leprosy model identifies interferon and plasminogen signaling as survival determinants in mycobacterial infection

This paper uses a zebrafish model of leprosy to identify interferon and plasminogen signaling as critical for survival in mycobacterial infection, using RNAseq and CRISPR screening.

Animal model of leprous neuritis using transfer of sensitized lymphocytes into M. leprae-inoculated nude mice

This study develops an animal model of leprous neuritis using sensitized CD4+ T cells in M. leprae-inoculated nude mice, showing immune-driven nerve damage and myelin loss.

Minimal effective dose of telacebec administered orally in a murine model of leprosy

This study determines the minimal effective oral dose of telacebec against M. leprae in a mouse model, finding 20 mg/kg achieves complete bacterial clearance.

CD1a-Mediated Presentation of Canonical Microbial Peptides to T Cells

This study identifies CD1a-restricted T cell responses to canonical microbial peptides in leprosy, expanding the known ligands of CD1a and suggesting potential applications for mycobacterial immunity research.

Evaluating a SNP calling pipeline for Mycobacterium leprae

The paper evaluates a SNP calling pipeline for Mycobacterium leprae using simulated reads and finds it robust and accurate with low false positives.

A systems biology investigation to identify potential bi-omarkers in leprosy-affected host cells.

This study identifies potential biomarkers in leprosy-affected host cells by analyzing RNA-Seq data and experimental results from armadillos, finding 25 proteins and three key biomarkers linked to leprosy pathogenesis.

Computational Saturation Mutagenesis to predict structural consequences of systematic mutations on protein stability and rifampin interactions in the β subunit of RNA polymerase in Mycobacterium leprae