Conserved T cell receptor usage underpins recognition of CD1c presenting a mycobacterial lipid
Thinh-Phat Cao, Caroline Soliman, Samuel J. Redmond, Tori Tappen, Jade Kollmorgen, 耿其吉, David Branch Moody, Thomas J. Scriba, Adam P Uldrich, Adriaan J. Minnaard, Chetan Seshadri, Hariprasad Venugopal, Adam Shahine, Jamie Rossjohn, Dale Ian Godfrey, Nicholas A. Gherardin
The paper identifies a conserved TCR motif recognizing mycobacterial lipids presented by CD1c, showing higher frequencies in TB-endemic regions and providing a cryo-EM structure of the interaction.
bioRxiv · Jun 22, 2026 · PreprintImmunology