Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- BioengineeringJournal of Biomedical Materials Research Part APeer-reviewed6 citationstop 5%
- BioengineeringJournal of Extracellular VesiclesPeer-reviewed
Magnetically Labeled iPSC-Derived Extracellular Vesicles Enable MRI/MPI-Guided Regenerative Therapy for Myocardial Infarction
Wenshen Wang, Zheng Han, Safiya Aafreen…·Guanshu Liu
This study develops magnetically labeled iPSC-derived extracellular vesicles for MRI/MPI-guided myocardial infarction therapy, showing improved cardiac function and detectability.
17 citationstop 3% - BioengineeringJournal of Biomedical Research & Environmental SciencesPeer-reviewed
HIF-1α promotes osteogenic-angiogenic coupling response of BMSCs cell sheets
Dan Zhang, Yonghui Teng, Wei Liu…·Hanwen Zhang
This study shows HIF-1α enhances osteogenic-angiogenic coupling in BMSCs cell sheets, promoting bone formation and vascular network development in vitro.
DOI 10.37871/jbres2201 - BioengineeringbioRxivPreprint
Flow Autoencoders are Effective Protein Tokenizers
Rohit Dilip, Evan Zhang, Ayush Varshney, David Van Valen
The paper introduces Kanzi, a flow-based tokenizer for protein structures that simplifies training and outperforms existing tokenizers on reconstruction metrics.
DOI 10.1101/2025.10.01.679645 - BioengineeringNature CommunicationsPeer-reviewed
Cassini: Streamlined and Scalable Method for in situ profiling of RNA and Protein
Nicolas Lapique, Michael Tae-jong Kim, Nicholas Thom…·Evan Z. Macosko
Cassini enables cost-effective, multiplexed profiling of mRNA and protein in tissue samples with high sensitivity and speed.
1 citation - BioengineeringJournal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materialsPeer-reviewed
Shaping the mechanical properties of a gelatin hydrogel interface via amination
Génesis Ríos Adorno, Kyle B. Timmer, Raul A. Sun Han Chang…·Brendan A.C. Harley
This study modifies gelatin hydrogels through amination and thiolation to improve mechanical properties of stratified biomaterials for tissue engineering.
3 citations - BioengineeringBioelectromagneticsPeer-reviewed
Human Skin Model from 15 GHz to 110 GHz
Andreas Christ, Adrian Aeschbacher, Bernadetta Tarigan…·Niels Kuster
This paper develops dispersive dielectric models for skin reflection and absorption across 15-110 GHz frequencies to ensure compliance with electromagnetic safety standards for wireless devices.
DOI 10.1002/bem.70025 - BioengineeringAdvanced Composites and Hybrid MaterialsPeer-reviewed
Homogeneously crosslinked in situ hydrogel enclosing high-density human-cancer cells promotes vascularized in vivo tumor modeling for immune cell therapy
Ziqi Huang, Yip Ming Tsun, Chao Liang…·Sang Jin Lee
This paper develops a degradable hydrogel for in vivo tumor modeling that supports vascularization and immune cell therapy testing in mice.
4 citations - BioengineeringbioRxivPreprint
Rational Design of Multiclade Coronavirus Spike Immunodominant Domain Nanoparticles Elicit Broad Antibody Responses
Christian K. O. Dzuvor, Sydney P. Moak, Lindsay R. McManus…·Kizzmekia S. Corbett
The paper designs multiclade coronavirus spike immunodominant domain nanoparticles that elicit broad antibody responses against multiple EhCoVs and SARS-CoV-2 variants in mice.
2 citations - BioengineeringCommunications BiologyPeer-reviewed
xIV-LDDMM Toolkit: A Suite of Image-Varifold Based Technologies for Representing and Mapping 3D Imaging and Spatial-omics Data Simultaneously Across Scales
Kaitlin M. Stouffer, Xiaoyin Chen, Hongkui Zeng…·Michael I. Miller
The paper introduces xIV-LDDMM, a toolkit for cross-scale and cross-modality mapping of 3D imaging and spatial-omics data using image-varifold measures.
DOI 10.1038/s42003-025-08800-7 - BioengineeringNature CommunicationsPeer-reviewed✦ In-depth digest
Protein corona formed on lipid nanoparticles compromises delivery efficiency of mRNA cargo
Elizabeth Voke, Mariah Lynn Arral, Henry John Squire…·Markita Patricia Landry
A 16-hour continuous iodixanol density gradient workflow isolates lipid nanoparticle protein coronas from human plasma and shows that vitronectin and C-reactive protein coronas impair mRNA delivery in liver cells.
129 citationstop 1% - BioengineeringbioRxivPreprint
SONIC: A Benchmarking Paradigm for Brain-Computer Interfaces
Sean M. Perkins, Michael Trumpis, Michael E. Reitman…·Vikash Gilja
This paper introduces SONIC, a benchmarking paradigm for BCIs, demonstrating an ITR of over 200 bps using an ovine model and the Connexus BCI.
2 citations - BioengineeringbioRxivPreprint
Isolation of structural constraints by ensemble-conditioned protein sequence design
Richard W. Shuai, Ling Zhou, Gina El Nesr…·Po‐Ssu Huang
This paper introduces Caliby, a sequence design method that conditions on structural ensembles to improve designability while reducing native sequence recovery.
6 citations - BioengineeringbioRxivPreprint
Execution-aware agent harness for accessible and responsible synthetic biology automation
Yuan Gao, Lizhou Luo, Yujie Liu…·Tong Si
LabscriptAI translates natural language into robot scripts for synthetic biology, achieving high simulation accuracy and enabling secure, standardized, and traceable lab automation.
- BioengineeringbioRxivPreprint
Polysialic Acid Presentation on Microporous Scaffolds Supports Neural Repair after Ischemic Stroke
Yunxin Ouyang, Sanchuan Che, Hannah Newman…·Tatiana Segura
This study shows that PSA-MAP scaffolds enhance early neural regeneration after ischemic stroke by increasing progenitor cells and axonal content without significant changes in astrocytic or vascular coverage.
- BioengineeringbioRxivPreprint
Enhancement of mRNA translation efficiency through 5'-UTR engineering
Esther Broset, Irene Blasco-Machín, Verónica Lampaya…·Juan Martínez-Oliván
This study enhances mRNA translation efficiency by engineering Kozak repeats in the 5'-UTR, showing improved expression in both cell culture and mice.
- BioengineeringVaccinePeer-reviewed
Expression and Characterization of SARS-CoV-2 Spike Protein in Thermothelomyces heterothallica C1
Yakir Ophir, Justin Wong, Katherine R. Haddad…·Somen Nandi
This study shows that the filamentous fungus Thermothelomyces heterothallica C1 can produce thermostable SARS-CoV-2 spike protein with a human-like glycan profile, comparable to mammalian systems.
- BioengineeringbioRxivPreprint
Efficient Protein Engineering via Integrated Language Models and Bayesian Optimization
Joshua Meehl, Prasad Siddavatam
This study uses protein language models and Bayesian optimization to improve protein engineering efficiency by predicting function from sequences and optimizing variant search.
DOI 10.1101/2025.09.30.679490 - BioengineeringbioRxivPreprint
Bone Resists Fatigue Through Crack Deceleration at the Fibril Scale
Riti Sharma, Stephen Ching, Luc N. Capaldi…·Ottman A. Tertuliano
This study observes crack propagation in human bone under fatigue loading, revealing nanoscale mechanisms that decelerate crack growth and suppress damage accumulation.
- BioengineeringbioRxivPreprint
Photoacoustic imaging assessment of acute kidney injury associated with experimental necrotizing enterocolitis
Anchala Guglani, Angadh Singh, Maryssa A. Ellison…·Victoria G. Weis
This study assesses acute kidney injury in a neonatal rat model of necrotizing enterocolitis using photoacoustic imaging and finds reduced renal oxygen saturation as a non-invasive biomarker.