Discover, rate, and discuss biology preprints.

The paper introduces a novel sludge treatment process called SPREAD that significantly improves organic loading rates and nutrient recovery in waste activated sludge treatment.

This study develops a cost-effective, printed graphene-based platform for in vitro cardiac electrophysiology, demonstrating its ability to record electrophysiological activity and respond to chemical stimulation.

This paper develops a 3D-bioprinted model of pulmonary artery adventitia using female patient-derived cells to show that estrogen signaling mediates fibroblast activation in PAH, with implications for drug testing.

This study investigates how hypoxia affects hematopoietic stem and progenitor cells in an engineered bone marrow model, showing improved cell maintenance under hypoxic conditions when oxygen shock is reduced.

This study investigates how GLP-1R signaling shapes β-cell heterogeneity by analyzing calcium dynamics in islets from different mouse models and humanized KO mice.

This study creates zonated liver organoids using hESCs-derived hepatocytes and LSECs, showing that GLP-1RA targets LSECs to alleviate NAFLD.

The paper develops a high-throughput assay to study neutrophil recruitment and function in an air-blood barrier array, showing improved throughput and sample efficiency compared to existing methods.

This paper introduces a mesoscopic SCAPE microscope with a super-oblique light sheet and rescanning strategy, achieving high-resolution volumetric imaging over large fields of view.

The paper introduces Latentverse, an open-source toolkit for evaluating latent representations, providing reports and visualizations on properties like clustering and robustness.

This paper introduces a new transfection method using hydrophobic ion pairing (HIP) that achieves efficient siRNA delivery in multiple cell types and organs with low toxicity.

This paper presents a wireless EEG sensor network platform that enables flexible, discreet, and robust multi-channel EEG recordings with reduced motion artefacts.

This study engineers biomimetic fibrocartilage grafts for TMJ reconstruction using MSC spheroids and micron-sized fiber scaffolds, achieving structural and ECM similarities to native tissue.

This study evaluates DNA origami-based nanoagents' ability to induce apoptosis in 3D spheroids, finding that rigid FasL attachment strategies are more effective than flexible ones.

This study identifies functional senescence subtypes in aging human dermal fibroblasts using single-cell morphology and machine learning, showing subtype-specific responses to senotherapies.

This paper introduces EDGE, an electrochemical method to modulate gene expression using DNA triplexes, showing that triplexes inhibit gene expression in cell-free systems.

This study develops methods to culture human and animal airway explants for at least 14 days, preserving tissue architecture and enabling study of health, disease, and viral infection.

This study improves tFUS targeting specificity using a phase-reversal correction method with a random array transducer, showing significant increases in focal overlap and energy delivery.

This paper develops a biomimetic polyurethane membrane that mimics lung alveolar tissue mechanics and supports long-term cell culture.

This paper combines odor sensory tests with computational models to quantify olfaction dynamics and predict odor intensity based on physiological parameters.

This paper introduces DSR, an ultrasound imaging method that super-resolves individual cells using acoustic deactivation of genetically encoded contrast agents, demonstrating its ability to localize mammalian cells beyond conventional resolution.