Discover, rate, and discuss biology preprints.

This paper introduces opMCI to measure physiological synchrony in parent-infant dyads and shows it increases after a shared reading intervention in preterm infants.

This study examines how input data variations affect lower-body torque predictions using wearable sensors and neural networks, finding dataset quality more important than input variables.

The paper shows that increased cell surface sialylation enhances DNA nanocage uptake by remodeling the membrane and recruiting caveolae-mediated endocytosis in RPE1 cells.

This paper investigates the use of Gordonia rubripertincta for syngas fermentation to produce carotenoids, finding optimal conditions for carotenoid yield.

PAIR combines CRISPR activation and RNA knockdown to study bidirectional gene interactions in DNA repair, revealing strategies to enhance CRISPR-based gene editing precision.

The paper designs a biobetter version of cetuximab with enhanced EGFR affinity using ConvergeAB, showing improved binding without compromising developability.

This paper introduces a real-time mmWave radar framework for activity classification and tracking in dementia home monitoring, achieving high accuracy in detecting stationary, walking, and absent states.

This study modifies the p5 terminal resolution site in AAV vectors to reduce encapsidated plasmid backbone DNA, improving vector safety and yield.

This study evaluates the thermal conductivity of plant and bacterial cells as potential biodegradable thermal insulation materials, finding low thermal conductivity and stable performance.

This study improves an Escherichia coli strain for high-yield L-malate production by modifying allosteric regulation, redox balance, and transport, achieving a mass yield of 1.2 g malate per gram of glucose.

The paper introduces a test-tube directed evolution platform that enables high-throughput screening without specialized equipment, achieving significant enzyme improvement in catalytic efficiency.

This paper develops an adhesive silk hydrogel patch for localized and sustained delivery of stem cell-derived nanovesicles, showing anti-fibrotic effects in vitro and in a mouse model.

This study uses electrical stimulation to replicate natural spiking activity in primate retinal neurons, achieving lower variability than visual stimuli.

This study develops a conductive hydrogel coating for radiofrequency ablation catheters to improve tissue contact and energy transfer, reducing collateral damage and recurrence.

The paper introduces GEM multinozzle printheads to accelerate ink formulation by enabling parallelized printing and combinatorial ink mixing for complex 3D structures.

The paper develops an agent-based model to show how senescent cell behavior and tissue mechanics contribute to pulmonary fibrosis in aged mice.

This study shows fibrous granular scaffolds with directional persistence guide myotube organization better than isotropic scaffolds.

The paper investigates the role of a dynamic loop in AvPAL by engineering disulfide bonds to restrict its mobility, revealing its regulatory function in substrate specificity.

This paper introduces a microfluidic platform called directoids to study directional axonal growth between neural organoids, showing robust directional bias in axon outgrowth.