Discover, rate, and discuss biology preprints.

This study uses molecular dynamics simulations to show that two structures of uncleaved HIV-1 Env, assigned to the same conformational state, exhibit distinct dynamic behaviors.

This study shows that increasing flagellation in E. coli improves its ability to swim against and across fluid flow by enhancing propulsion and directional control.

The paper models how oxidative lesions at specific sites in the ABCB1 linker affect its structure and function, suggesting a potential mechanism for transporter regulation.

This study compares the accuracy of two single-molecule localization methods in microscopy, finding that MINFLUX significantly outperforms camera-based methods.

This study uses Raman spectroscopy and acoustic microscopy to identify biophysical markers of glioblastoma resistance, finding distinct biochemical and mechanical differences between resistant and sensitive cells.

This study observes freshwater blackworms navigating a maze with food in the center, showing entry into the central chamber but no evidence of food localization or chemotaxis.

Paramecium tetraurelia partitions its ciliary array into a dense, fast-beating domain anterior to the oral apparatus that drives feeding flows and a sparser, slower domain that drives swimming.

This study shows tau forms multilayered condensates on microtubules via a prewetting-like transition, creating a selective microenvironment that restricts some proteins while recruiting others.

The paper identifies the glycine-tyrosine-glycine motif as a key site for ice-like water ordering in bacterial ice-nucleating proteins through molecular dynamics simulations.

The paper shows invasive breast cancer clusters self-organize through active nematic dynamics interacting with passive ECM nematic structures, with higher activity linked to worse patient outcomes.

This study uses cryo-EM to determine the structure of a light-regulated bacterial two-component system, revealing how light affects signaling through changes in histidine kinase and response regulator interactions.

This study uses optical tweezers to measure the mechanical properties of human centromeres, revealing stiffness at low forces and softening under tension, with implications for chromosome segregation.

This study identifies the cytoplasmic coupling domains of TRPV1 as the temperature-responsive region using simulations and analysis of contact networks.

This study uses molecular dynamics simulations and Markov state models to compare activation mechanisms of tyrosine kinases, revealing kinase-specific conformational ensembles.

This study shows the RIG-I 2CARD acts as both a signaling module and a brake on dsRNA translocation using high-speed atomic force microscopy.

This study measures the energetic cost of bacterial motility using microcalorimetry and finds it to be a significant portion of total metabolism during starvation.

This study quantifies how brown trout parr respond to rapid temperature changes by avoiding cold water and crossing warm water interfaces.

This paper introduces edge-aware graph attention networks to interpret biophysical mechanisms from molecular dynamics simulations, showing improved prediction and communication network analysis.

AnDi-J is a Fiji plugin that analyzes single-particle tracking data using classical and machine learning methods to extract diffusion properties and classify trajectories.

This paper develops a biophysical model of loop extrusion that links motor dynamics to chromatin accessibility and compaction, revealing how nucleosome spacing affects extrusion speed.