Discover, rate, and discuss biology preprints.

The paper develops an energy barrier model for membranes to analyze ion flow, current-voltage relations, and Donnan osmosis.

This study uses molecular dynamics simulations to show that lipid asymmetry, specifically LPC and PIP2 conversion, affects membrane structure and curvature.

This study uses photoswitchable lipids to control membrane remodeling in giant vesicles, showing how domain architecture influences light-induced mechanical responses.

This study identifies that T cells achieve maximal migration speeds by combining bleb formation with adhesion-based forces, challenging the feasibility of adhesion-free migration.

This paper compares volume and surface methods for microparticle traction force microscopy through simulations and experiments, finding the surface method more accurate but with reduced performance at high noise levels.

This paper introduces an oligo DNA-based method for multicolor quantum dot single-particle tracking, enabling accurate imaging of membrane molecules in living cells.

This paper introduces a two-tier approach to study kinematic modulation in fish schools, finding that schooling fish exhibit higher positional and kinematic modulation than solitary fish, aiding energy conservation.

This paper introduces a method to measure cellular traction forces in 3D tumoroid cultures using elastic microparticles, revealing cellular stress ranges and interactions with the extracellular matrix.

This study investigates how different polymer nanoparticles penetrate the blood-brain barrier using molecular dynamics simulations, finding that polyethylene and polypropylene show strong preference due to their hydrophobicity.

This paper introduces a Holotomography-driven learning method for virtual staining in flow cytometry without requiring co-registration, enabling label-free single-cell analysis.

This paper develops a method to perform three-dimensional single-particle reconstruction using AFM for rapid structural validation of proteins, demonstrated on SARS-CoV-2 Spike protein.

The paper uses experiments and a mathematical model to show that higher agar density increases yeast biofilm adhesion and decreases nutrient uptake.

This study uses NMR peak intensity analysis to identify functional dynamics hotspots in proteins, showing that specific structural flexibility correlates with function in red fluorescent proteins.

The paper uses real-time imaging to study replisome rotation during DNA synthesis, finding that high-speed rotation supports continuous synthesis but reduces processivity and increases polymerase numbers.

The paper identifies and characterizes a nanobody, Sb32, that binds thermostable GFP (TGP) with nanomolar affinity and reveals an unusual binding mechanism involving CDR2 and hydration networks.

This paper introduces a real-time nanopore data analysis method that estimates protein size and shape with low latency, improving feedback control and data efficiency.

This paper introduces fluorescent peptide probes based on GsMTx4 to measure two-dimensional membrane tension and domain structure in biological membranes.

This study develops a mechanobiological model to show how extracellular viscosity affects cancer cell migration through actin dynamics and adhesion, revealing a biphasic response and migration memory.

The paper presents a systematic method for purifying fluorophore-labeled proteins using anion exchange chromatography, achieving high yields for FRET studies.

The paper describes a Kaggle competition for RNA 3D structure prediction, showing that template-based methods can outperform deep learning approaches.