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This paper develops a novel protocol to measure root hair growth mechanics under force, validating the Lockhart viscoplastic model and estimating turgor pressure and cell wall viscosity in Arabidopsis.

The paper uses native mass spectrometry to study ATP binding to Rho, revealing binding to hexameric and lower-order complexes and super-stoichiometric binding at partially formed sites.

The paper models mechanochemical coupling in optogenetically activated cell layers using a finite element framework to understand signal propagation and cell responses.

This study investigates how repulsive and attractive crowding environments affect TDP-43 condensates through distinct physical mechanisms and structural dynamics.

This paper optimizes adhesion methods for cryo-electron tomography of vitreous sections, increasing throughput to match thin film methods and enabling high-resolution imaging of molecular complexes.

This study models the full-length HIV-1 Env trimer with a lipid bilayer and uses molecular dynamics to analyze its conformational flexibility and implications for viral entry and antibody accessibility.

This study investigates how RNA structure and sequence context influence RAN translation initiation in C9orf72 repeats, revealing a kinetic bottleneck in initiation at near-cognate start codons.

This study identifies structural dynamics and regulatory mechanisms of SK1, revealing a novel inhibitory paradigm and insights for therapeutic development.

This study investigates how Ca2+ and Zn2+ bind to human protein Z, affecting its structure and membrane association, and their impact on PZ-ZPI complex stability.

This study reveals how palmitoylation of PSD95 reorients its domains to promote membrane association and clustering, with lipid composition modulating this process.

This study constructs a full-atom model of the NisFEG transporter in the ATP-bound state, revealing structural asymmetry and interaction mechanisms critical for nisin extrusion and bacterial immunity.

This paper describes a system using DNA origami to control directional membrane budding, mimicking virus assembly and producing DNA-shelled vesicles with applications in drug delivery and synthetic biology.

This study evaluates the quality of machine learned reaction coordinates using the gamma metric and shows an inverse correlation with accelerated times.

The paper reveals how thermodynamic principles shape the biophysical properties of proteins through allosteric regulation and evolutionary tradeoffs.

This paper introduces a low-cost smartphone-based microscope capable of single-molecule detection and super-resolution imaging without signal amplification.

This study demonstrates that disulfide-cross-linked peptide condensates efficiently deliver various molecular cargos, including DNA and mRNA, into HeLa cells with higher transfection efficiency than commercial agents.

This study uses high-speed AFM to examine how amyloid-β and cholesterol affect the dynamic stability of lipid domains in model membranes.

The paper introduces a model to study how proteins transmit information over long distances without structural changes, finding that discrete motion enables this despite thermal noise.

The paper analyzes first passage time fluctuations and resetting protocols in three biochemical systems with two-state toggling, showing non-monotonic behavior and re-entrant transitions in resetting efficacy.

GROMODEX optimizes GROMACS MD simulations using a Design of Experiments approach, improving performance across different hardware and molecular systems.