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The paper analyzes Hydra morphogenesis to show that shape fluctuations become more concentrated over time, indicating dynamical canalization linked to spatial calcium heterogeneity.

The paper shows how extracellular matrix stresses spatially bias myoblast fusion and myotube growth through nematic organization and mechanical feedback.

The paper investigates the M899I variant in Nav1.7, showing it causes pore collapse, leading to loss of sodium currents and pain insensitivity.

Morpheus-3D detects and localizes fold-switching proteins using sequence-based entropy profiles, outperforming existing methods and revealing widespread structural plasticity across proteomes.

This paper develops a Bayesian framework to model radiation damage in cryo-EM datasets by inferring atomic displacements and structural changes during electron irradiation.

The paper develops two models to estimate internal temperatures in a near-term fetus, showing they align with measured temperatures and demonstrate how changes in umbilical cord heat exchange affect fetal temperatures.

This study identifies two antibodies that recognize conserved SARS-CoV-2 RBD epitopes, revealing structural mechanisms for broad neutralization and escape pathways.

This paper develops a fluorescent ATP analog to study nucleotide binding sites on KATP channels, showing that non-hydrolyzable ATP analogs can bind to SUR1 sites and do not fail to activate KATP due to binding issues.

The paper uses an active vertex model to show that spatial velocity correlations can distinguish four modes of epithelial activity based on their spatial organization and dynamics.

This study shows that secondary nucleation increases polymorphic diversity in hIAPP amyloids, and molecular chaperones can steer aggregation toward a monomorphic state.

This paper develops a computational method to map full 3C-3D blood flow in the beating zebrafish heart using SPIM and microPIV techniques.

The paper develops a graphene device for high-temperature crystallography to study enzymatic reactivity across temperature ranges, revealing how transition state ensembles relate to catalytic rates.

This study shows clathrin alone can drive membrane fission in vitro, with stronger assembly leading to weaker fission, suggesting lattice curvature, not just recruitment, drives membrane remodeling.

The paper introduces a dataset of VHH-Fc antibodies and shows that IgG-trained models outperform VHH-Fc-specific models in predicting developability properties.

This paper develops a mechano-piezoelectric peptide hydrogel that modulates stem cell and immune niches to reverse osteoarthritis by combining piezoelectric cues with 4-OI loading.

This paper stabilizes and analyzes the singly-bound intermediate of chorismate mutase to reveal that positive cooperativity arises from dynamic ensemble behavior rather than a simple two-state switch.

This study uses synchrotron nano-FTIR to show that carbohydrate-coated nanoparticles induce protein conformational changes in E. coli at the nanoscale.

This paper introduces ARCHER, a method for cross-specimen cryo-EM pose estimation that generalizes across structures using a contrastive classifier trained on protein structures.

This paper develops a coarse-grained model of synapsin aggregation and shows that weak interaction features significantly affect collective organization at mesoscopic scales.

This study investigates how membrane phase, charge, and curvature jointly regulate α-synuclein binding dynamics using experimental and simulation methods.