Discover, rate, and discuss biology preprints.

This study investigates surface phase separation in confined spaces, identifying three wetting states and explaining droplet formation under specific conditions.

This study shows that Piezo1 channels in cell-derived membranes exhibit mechanical gating and adopt a flattened shape, requiring both mechanical force and a membrane-derived cofactor for activation.

The paper develops a method to image and analyze cilia-driven transport in mammalian tissues using light-field microscopy and flow reconstruction, revealing conserved flow structures across different tissues.

This study identifies four recurrent dengue envelope protein interaction architectures using computational methods and suggests viral stability depends on local network context.

This study investigates how ATP and ADP binding affects MreB polymerization and membrane interaction in Geobacillus stearothermophilus, revealing distinct binding affinities and membrane fluidizing effects.

This study investigates whether mechanical forces during collective epithelial migration can trigger cytoplasmic liquid-liquid phase separation, showing feedback effects on motility.

The paper investigates how intramolecular interactions between folded and disordered regions of ubiquilin proteins influence their structure and function across different species.

This study shows that the stiffness ratio between spinal cord gray and white matter changes with indentation bead size, depending on the anatomical plane.

This paper designs intrinsically disordered proteins using a physics-guided machine learning framework to encode complex signal processing and condensate properties.

This study uses single-cell electrophysiology to show verapamil disrupts bacterial membrane energetics by selectively dissipating the electrical component of the proton motive force, distinct from classical protonophores.

This study models the structure of LRP1 using homology and neural network-based methods, revealing glycan-mediated dimerization and its role in stabilizing the protein's quaternary structure.

The paper calculates photon requirements and radiation dose for X-ray fluorescence microscopy using single excitation energy to detect low-concentration elements in biological tissues.

The paper develops a self-consistent model to study phase separation and active processes in biomolecular condensates, showing how scaffold activity regulates phase behavior and enhances client transport near stability thresholds.

The paper determines the atomic structure of insect chorion amyloid filaments and reveals their assembly principles, showing functional amyloids can operate in a regulated biological context.

The paper uses Bayesian inference to determine bond parameters between vimentin filaments from force trajectories measured with optical tweezers.

The paper introduces MuH-MDS, a hyperbolic embedding method that scales to large datasets and improves hierarchical structure analysis in biological data.

This study develops a simulation platform to model microswimmers and explores morphology-function relationships across species.

This study quantitatively compares the membrane binding and self-assembly of human septin hexamers and octamers using biophysical methods, revealing distinct structural properties and functional implications.

This study shows that spin selectivity affects extracellular respiration in living Geobacter sulfurreducens biofilms, demonstrating a quantum effect in cellular metabolism.

FINDER enables attomolar biomarker detection by converting kinetic fingerprinting into area-scalable sensitivity without amplification.