Discover, rate, and discuss biology preprints.

This study shows that disordered protein sequences encode characteristic small molecule binding pathways, identified through molecular dynamics simulations and machine learning.

The paper develops a stickiness scale for disordered proteins based on biophysical experiments and compares it to existing hydropathy scales.

This paper develops a dual-color BRET biosensor to monitor SARS-CoV-2 protease cleavage kinetics in live cells, revealing differential cleavage rates and drug potency.

The paper introduces a framework to decompose protein folding flux into pathway-specific kinetic contributions, revealing hidden kinetic hierarchies in folding mechanisms.

This study shows that tuning siRNA packing order in lipid nanoparticles improves functional delivery by enhancing silencing potency through less compact packing.

This study solves cryo-EM structures of SpyCas9 bound to minicircle DNA, revealing how DNA shape affects Cas9 target interrogation and cleavage.

The paper develops a pipeline for deep imaging and analysis of multi-layered organoids, revealing gene expression patterns and nuclear morphology in gastruloids.

This study develops a model to show how mechanical forces regulate coronavirus entry by strengthening ACE2 binding and promoting spike protein disassembly.

This study uses multiscale simulations to reveal how SDS disrupts MS2 bacteriophage capsid, showing pH-dependent effects and molecular mechanisms of surfactant-virus interaction.

This study shows that aging emerges from unavoidable damage and energetically constrained turnover, demonstrating that these factors can generate aging-like decline in biological systems.

This study experimentally confirms sequence-dependent poloidal orientations in DNA minicircles using atomic force microscopy.

This study uses quantitative MRI to show that iron aggregation, not just concentration, drives MRI contrast changes in ACP patients.

This study shows vimentin enhances nuclear deformation in polarized cells by linking to nesprin-3 and transmitting forces through the nuclear envelope.

The paper develops a biomechanical model to study how cells remodel fibrous matrices to drive durotactic migration, showing collective behavior similar to cancer metastasis.

This study uses interferometric light microscopy to rapidly and accurately quantify and characterize isolated mitochondria, offering a label-free alternative to traditional methods.

This study shows cGAS forms a protein-dsDNA mesh that enables dsDNA-specific and length-dependent activation through higher-order assembly.

This paper studies DNA nanomotifs anchored to lipid bilayers, showing they undergo two-dimensional phase separation based on sticky end interactions, independent of lipid phase separation.

This paper introduces a deep learning method to identify conformational binding signatures in protein dynamics from molecular simulations.

The paper investigates interfacial mechanics of biomolecular condensates, finding critical-like behaviors such as reduced surface tension and bending elasticity near phase boundaries.

This paper introduces a quantitative imaging framework to study GPCR oligomerization in living cells, revealing density-dependent monomer-dimer equilibria and apparent affinities for dimerization.