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This study uses patient-derived iPSC cartilage organoids to show defective ECM deposition and altered chondrogenic trajectory in Saul-Wilson syndrome.

This study shows that replication stress from MCM2-7 mutations impairs placenta development in mice by reducing junctional zone proliferation and stemness, leading to poor embryo viability.

The paper tracks Flt3+ hematopoietic progenitors in vivo to show their lineage-restricted fates and long-lived output in immune cell compartments.

The paper develops a workflow to map metabolic neighborhoods in neural rosettes using MALDI imaging and single-cell analysis, enabling spatial and metabolic characterization of differentiating stem cells.

The paper examines the role of symbiotic algae and heterotrophic feeding in the development of asexual offspring in Aiptasia, showing that symbionts enhance growth under feeding but hinder development under starvation.

The paper uses 3D imaging to analyze vascular and nervous systems in embryos, finding shared structural principles but distinct architectures shaped by biophysical constraints.

This paper introduces EmbryoTempoFormer, a model that infers developmental tempo from zebrafish time-lapse microscopy, showing that temperature changes alter developmental progression through tempo rather than time offset.

The paper shows that loss of MITF activity in zebrafish melanocyte stem cells leads to premature expansion and novel transcriptional states during embryogenesis, with stage-specific effects on regeneration.

This study shows that TET-dependent DNA demethylation is essential for retinal development, as its disruption leads to blindness by altering cellular composition and photoreceptor function.

This study identifies STAT1 as a suppressor of PDGFRβ-driven overgrowth in a mouse model of KOSAKI overgrowth syndrome.

This study shows that fetoplacental circadian rhythms develop in utero and synchronize with the mother, with maternal glucocorticoids playing a key role in this synchronization.

This study identifies chondrolectin as a regulator of satellite cell localization and regenerative function in mice through single-cell RNA-seq and knockout models.

This study shows that low-level chemical exposure during pregnancy in sheep leads to sex-specific, heritable DNA methylation changes across generations, with some effects persisting in unexposed descendants.

The paper identifies key regulatory elements in bat limb development by comparing bat and mouse genomic datasets and swapping enhancer sequences to observe phenotypic changes.

The paper shows that cleavage of histone H2A by Cathepsin L during ESC differentiation reduces nucleosome stability and counteracts gene activation.

The paper identifies a glial attachment mechanism in C. elegans neurons that affects cilia morphology and function.