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The paper identifies PALS-22 as a regulator of AGO expression in C. elegans, showing its role in balancing immunity and germline health through modulation of RNAi and epigenetic inheritance.

RetiGene provides a curated gene atlas for inherited retinal diseases, integrating variant data and RNA sequencing to support gene prioritization and therapeutic development.

The paper introduces diplo-locus, a Python toolkit for simulating and inferring parameters from time-series genetic data under diploid selection models.

CACTI improves cQTL mapping by using correlations between regulatory elements, identifying more signals and colocalizing with GWAS loci better than traditional methods.

The paper develops a framework to estimate genetic and social homogamy using family data and finds that indirect assortative mating better explains educational attainment similarities than direct assortment.

This study tests a homing gene drive in Drosophila melanogaster and finds that while simple resistance alleles can emerge, complex resistance is unlikely due to no heritable genetic effects on drive efficiency.

This paper introduces solveblock, a software tool that enables FDR-controlled conditional independence analysis using GWAS summary statistics, leading to additional discoveries in British individuals.

This study compares phase-free and phase-based local ancestry inference methods, finding phase-free methods provide more accurate results despite lower phase quality.

This study examines epigenetic changes in Borrelia-infected ticks, finding increased EHMT2 expression but no change in DNA methylation of specific repeats.

This study identifies transposon activities as key drivers of sweet orange cultivar selection and diversification over the last 500 years.

DNACipher predicts variant effects across cell types and assays, identifying imVars at most GWAS loci with support from experimental data.

This study identifies SAMM50 rs3761472 as a risk factor for MASLD by showing it causes mitochondrial dysfunction and metabolic impairments in mice.

The paper shows that an ATTTC repeat insertion in an Alu element enhances a DAB1 enhancer, leading to neuronal dysfunction in SCA37.

This study identifies SNP markers associated with environmental variables in European beech populations along an altitudinal gradient, highlighting potential genes involved in local adaptation to temperature and precipitation.

This study develops a DNA reference library for elasmobranch species in Sri Lanka using Oxford Nanopore Sequencing for fisheries monitoring and conservation.

The paper describes a high-efficiency method for homology-dependent genome editing in Cryptococcus neoformans using CRISPR/Cas9 and a Ku80 mutant strain.

This paper investigates how geographic breadth of sampling affects the discovery and frequency of rare, deleterious variants in genetic studies.

The paper shows that C. elegans transmit environmental information through lipid changes across generations, affecting offspring thermotolerance via a neuron-intestine-oocyte pathway.

This study identifies diencephalic and neuropeptidergic dysfunction in zebrafish with autism-risk mutations, revealing potential molecular and behavioral mechanisms.

The paper applies the MR-Horse method to reduce selection bias in GWAS of disease progression by accounting for genetic correlation and pleiotropy, showing reduced bias and controlled type 1 error rates.