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This study identifies tRNASec(NCA) damage as an aging hallmark and shows that targeting its 5'-fragment with ASO extends healthspan and lifespan in mice.

ConfuseNN evaluates how genomic features affect CNN performance in population genomics by systematically shuffling input data.

This study examines how CDC45 mutations affect DNA replication and genome stability, finding defects in replication initiation and increased mutation rates.

This study identifies an ALPK3 truncation variant causing HCM and shows that mavacamten partially rescues cardiac contractility and calcium handling defects in a mouse model.

The paper shows that Ancient DNA data from MZR is contaminated with modern Han Chinese ancestry, making it unreliable for population genetic analysis.

This paper introduces a selection-free CRISPR-Cas9 editing protocol effective across multiple Dictyostelid species, enabling efficient knock-out and knock-in mutations without antibiotic selection.

This study identifies core genetic drivers of chronological aging in yeast through meta-analysis and functional screens, revealing Tec1 and mitochondrial machinery as key regulators.

The paper identifies population-specific DNA methylation patterns in African and European populations and links them to genetic variants and disease-related genes.

This study uses genome-scale CRISPR screening to identify LDLR and MYLIP as key regulators of Lp(a) uptake in HuH7 cells, with validation in a UK Biobank cohort.

The paper investigates the role of H3K4me3 at intergenic regulatory elements and finds it instructs RNA polymerase activity and is actively remodeled.

This study identifies genetic associations between posterior parietal cortex and intelligence, suggesting discrete intelligence capabilities.

This paper develops a systemic AAV-CFTR gene therapy approach for cystic fibrosis, demonstrating functional CFTR expression and lung transduction in non-human primates.

This study shows that hlh-3 expression is sexually dimorphic in C. elegans males and is required for the maturation of neurons involved in male-specific exploration behavior.

This study identifies L1TD1's role in promoting LINE-1 retrotransposition by interacting with L1 ORF1p, linking it to cancer progression and early development.

This study shows that artificial light at night disrupts circadian and metabolic gene expression in green anole lizards, with impacts on hormone regulation, glucose homeostasis, and potential reproductive cycles.

This paper introduces a likelihood-based framework called gLike to infer demographic history from genealogical trees, showing improved accuracy in estimating population parameters compared to existing methods.

This paper identifies the genetic region controlling prickle-free canes in tetraploid blackberries using GWAS and develops diagnostic markers for breeding.

The paper identifies unique signatures of highly constrained genes using gnomAD and explores their association with human disease and molecular pathways.

This study generates and characterizes conditional albino mutants in Exophiala dermatitidis that can recover melanin production under specific conditions.

This study shows that loss of Tbx4 in embryonic lung mesenchyme leads to postnatal lung developmental defects and increased pulmonary hypertension.