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The paper uses genetic data from Denmark and Britain to infer historical North Sea migrations from the Middle Ages to the Industrial Revolution, identifying distinct population patterns and migration trends.

This paper introduces a whole bacterial proteome foundation model trained on ESM embeddings to capture gene interactions and genomic integrity, achieving state-of-the-art results in operon identification and genotype-phenotype mapping.

The paper shows that a synonymous variant in PILRA decreases mRNA and protein levels by disrupting a ramp sequence, providing a biological mechanism for its association with Alzheimer's disease.

This study shows that genetic diversity improves the performance of intolerance metrics in identifying disease-related genes, with multi-ancestry data outperforming European-only datasets.

The paper identifies SNPs associated with postharvest blue mold resistance in wild apple germplasm using genomic sequencing and association mapping.

The paper develops a theoretical framework to analyze heterosis by estimating QTL effects and applies it to maize and rice datasets, finding dominance primarily drives heterosis in both.

The paper uses a coalescent model to show that all modern humans share deep ancestral structure from two populations that admixed ~300k years ago, with the minority ancestry linked to deleterious effects and majority ancestry linked to archaic human divergence.

This study compares polygenic scores from genotyping arrays and whole-genome sequencing across traits and populations, finding that WGS generally improves prediction accuracy but with context-dependent advantages.

The paper maps cellular states in yeast using a single-cell transcriptome atlas generated from genetic perturbations and identifies regulators of transcriptional heterogeneity.

The paper identifies LCORL and STC2 variants associated with increased body size and growth rate in cattle and other domesticated animals through genetic analysis and mouse models.

This study investigates the roles of P-body factors Dhh1 and Edc3 in Candida albicans filamentation and stress response, finding that Dhh1 is critical for growth, heat tolerance, and transcriptome regulation, while Edc3 is not required for these processes.

The paper develops a system to reversibly control UFA biosynthesis in C. elegans by targeting fat-7 while deleting fat-5 and fat-6, revealing its essential role in early development and lipid metabolism.

The paper uses in vivo single-cell CRISPR screening in mouse epidermis to identify a microprotein critical for ribosome function and cell proliferation.

The paper extends a machine vision-based frailty assessment tool to genetically diverse mice, enabling accurate prediction of frailty, age, and lifespan proportions using video data.

This study investigates BMD mice with specific exon deletions, showing site-specific muscle degeneration, type IIa fiber reduction, and capillary changes linked to nNOS reduction.

The paper investigates the functional impact of a GWAS-identified Myb enhancer in beta-thalassemia by generating a knock-out mouse model and analyzing its effects on erythropoiesis and clinical parameters.

This study investigates the transcriptional effects of disrupting nuclear RNAi in C. elegans, showing that while X chromosome decondensation occurs, global transcriptional de-repression is not observed, and HRDE-1 and NRDE-3 regulate their targets through distinct mechanisms.

The paper investigates the role of EZH2 in Duchenne muscular dystrophy and shows that inhibiting EZH2 improves muscle phenotype in Dmd mutant mice when combined with glucocorticoids.

This study shows that C1ORF106 and its IBD variant regulate intestinal barrier permeability by controlling tight junctions, cell polarity, and F-actin dynamics through a ROCK-dependent mechanism.

This paper uses ancestral recombination graphs to impute and trace rare variants in founder populations, showing high accuracy in mutation age and regional frequency estimation.