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This paper applies a multi-trait GWAS approach to non-European ancestries, identifying new associations and demonstrating increased replication of European loci.

This study investigates how haploinsufficiency of ribosomal proteins affects mitochondrial morphology, respiration, and stress responses in C. elegans and human cells.

This paper introduces PROSPER, an ensemble penalized regression method for multi-ancestry polygenic risk prediction, showing improved performance across diverse populations.

The paper introduces MAJA, a method for joint association testing in multi-omics data, finding shared epigenetic pathways across multiple traits in methylation data.

This study evaluates millet germplasm in Liaoning, China, identifying resources with desirable traits for breeding and practical applications.

This study shows splice modulators like branaplam reduce HTT CAG repeat expansion by affecting PMS1 expression, suggesting PMS1 as a new therapeutic target for Huntington's disease.

The paper shows that Pol II CTD phosphorylation, specifically Ser2 phosphorylation, is critical for activating a heterochromatic gene in yeast, suggesting an alternative mechanism to histone modifications.

Poseidon provides a framework for managing archaeogenetic data to ensure FAIR principles through open, interoperable tools and archives.

This study uses Cas9-directed long-read sequencing to validate and refine optical genome mapping findings in leukemia diagnostics, improving breakpoint resolution and clinical relevance assessment.

This paper analyzes confounding in population and family-based GWASs, showing family-based estimates can be biased by genetic confounding and interactions.

The paper uses trace DNA from kill sites to identify individual tigers, finding that shed hair samples are most effective for individual identification.

The paper identifies a CAD risk SNP rs880890 in an endothelial enhancer that reduces CALCRL expression by impairing HSF binding under shear stress.

This study identifies UTR mutations that disrupt translation by altering polysome profiles and RNA structures, with a focus on uORF initiation sites and SRSF2 binding motifs.

The paper identifies rare FN1 variants that protect APOEε4 carriers from Alzheimer's disease by modulating extracellular matrix deposition and gliosis.

The paper evaluates genotype imputation accuracy across global populations and finds disparities in performance for non-European ancestries, highlighting the need for more diverse reference panels.

The paper introduces an averaging model to better analyze high-order genetic interactions in multi-gene systems, addressing limitations of traditional additive models.

The paper analyzes DNA binding effects of 92 human homeodomain mutants, identifying 14 novel specificity-determining residues and highlighting limitations of variant effect prediction tools.

The paper introduces WPS2, a high-throughput and high-sensitivity scRNA-seq method, which improves gene and transcript detection in low RNA-content cells and nuclei.

The paper introduces 11 wild-derived inbred mouse strains with expanded genomic and phenotypic diversity, enhancing the scope of biomedical research.

The paper develops a universal set of microsatellite loci for baleen whale individual identification and parentage analysis, showing its utility across four species.