Discover, rate, and discuss biology preprints.

This study shows that piRNA pathway downregulation in the germline during mating releases Hedgehog signaling, leading to somatic aging and reduced lifespan.

The paper shows that yeast cells with elevated chromosome numbers are dependent on Mps1 for proper chromosome orientation during mitosis, revealing a mechanism for Mps1 addiction in aneuploid cells.

This paper introduces a method to detect rare DNA methylation outliers in schizophrenia and finds an increased burden of these outliers in cases compared to controls.

The paper investigates the functional interdependence of sister replisomes in E. coli, showing that their physical association in a factory configuration enhances replication efficiency and reduces fork stalling.

The paper identifies new alleles in eIF4E and eIFiso4E genes from Prunus species that are linked to resistance against Plum Pox Virus (PPV).

The GLAD Project compiles genome-wide data from 54,077 Latin Americans and develops tools for ancestry matching and statistical software evaluation in admixed populations.

The paper profiles H3K27ac in brain cell types from AD patients and finds acetylation differences in oligodendrocytes linked to AD risk genes and pathways.

FLARE infers local ancestry with high accuracy and efficiency, scaling to large datasets using advanced computational techniques.

This study investigates the role of BCL2L13 and autophagy in mtDNA purifying selection by analyzing knockout models in mice.

The paper identifies DNA methylation signatures associated with NSD2 loss-of-function variants and shows their similarity to those in Wolf-Hirschhorn syndrome.

The paper analyzes meiotic recombination in Lachancea waltii, identifying differences in crossover distribution, LOH events, and recombination hotspots compared to related species.

The paper presents a genetic toolkit to convert Gal4 strains into LexA and Flippase transgenes using genetic crosses and fluorescence screening, demonstrating its effectiveness with ten Gal4 lines.

This study performs a genome-wide association study of brain biochemical phenotypes in Alzheimer's patients, identifying novel genetic loci and highlighting distinct genetic architectures for AD-related proteins.

The paper identifies GPI-anchor biosynthesis as a conserved regulator of sleep through variant-to-gene mapping and cross-species genetic screening in humans and model organisms.

This study identifies novel regulators of Nutritional Compensation in the circadian clock of Neurospora crassa and shows conservation in mammalian cells.

This study presents the genome of M. brumae and shows its nonpathogenic and immunogenic traits through genomic analysis.

The paper introduces multiMiAT, a microbiome-based association test for multicategory phenotypes, showing it performs well in simulations and real data analyses.

The paper addresses spurious gene-environment interaction in case-parent trio data by adjusting for genetic principal components to account for exposure-related genetic structure across multiple population strata.

This study shows that holocentric Cuscuta species have lost the standard kinetochore and SAC, with gene loss and protein mislocalization observed.

This study shows that dietary restriction in Drosophila affects diurnal rhythms and longevity through clock-controlled proteasome subunits.