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This study shows that bacterial chromosomes can undergo chromatin assembly, activity, looping, and compartmentalization in yeast, driven by their sequence composition.

This study shows that the circadian clock gene bmal1 is necessary for circatidal rhythms in Eurydice pulchra, while other negative regulators are not.

The paper identifies abundant genetic pleiotropy across neuroimaging modalities using a multivariate genome-wide association study in two cohorts.

The paper identifies cutl-24 as a gene responsible for ER stress resistance in a Kenyan C. elegans isolate, showing parent-of-origin effects and validating its role through genetic experiments.

The paper characterizes the immunoglobulin lambda chain locus in diverse populations, identifying novel alleles and highlighting limitations of short-read sequencing.

The paper develops a high-resolution Y-SNP panel to infer paternal lineages and admixture history in Chinese populations, revealing complex genetic diversity and migration patterns.

The paper generates a visible eye color marker in Oncopeltus fasciatus through genome editing of the vermilion locus, identifying its role in pigmentation and creating a genetic tool for this species.

SPEER identifies abnormal mRNA splicing and assesses its clinical impact in hereditary cancer syndrome genetic testing, reclassifying variants of uncertain significance.

DeepGWAS enhances GWAS signals for neuropsychiatric disorders using deep neural networks, improving locus detection in schizophrenia and validating results in other disorders.

The paper shows that RNAi targets noncoding regions of VANDAL TEs, while VANC proteins evolved to escape this silencing, suggesting a co-evolutionary arms race between TEs and host defense mechanisms.

The paper investigates the effect of curcumin and verapamil on cardiovascular phenotype in a Williams-Beuren Syndrome mice model, finding reduced oxidative stress and improved cardiovascular outcomes.

The paper introduces a method to detect directional and non-directional epistasis in bi-parental populations using genomic data and applies it to maize and soybean populations, finding significant epistatic effects.

The paper estimates SNP heritability of de novo mutations in offspring using the 100k Genomes Project cohort, finding paternal but not maternal genetic contributions.

Shark-dust DNA sequencing reveals widespread trade in threatened sharks and rays, identifying 54 taxa including many CITES-listed species.

The paper identifies a non-coding variant that increases ICOS expression, leading to more T peripheral helper cells and contributing to autoimmune diseases.

The paper assesses genetic structure and connectivity of scalloped hammerhead sharks in the Eastern Tropical Pacific, identifying distinct populations and philopatric behavior, highlighting conservation needs.

The paper examines population structure and gene flow in the allotetraploid frog Xenopus laevis using genomic data from southern Africa, finding no strong evidence of subgenome differences and linking population structure to environmental factors.

The paper studies how cross-linkers generate chromatin phase separated nanoregions and quantifies their impact on molecular access using single particle trajectories.

The paper develops CRISPRme, a tool that integrates genetic diversity data to assess off-target risks of gene editing, finding allele-specific off-target effects in clinical gRNAs.

The paper identifies how ASXL1 mutations disrupt the epigenome and activate Wnt signaling pathways in Bohring-Opitz syndrome and myeloid leukemias.