Discover, rate, and discuss biology preprints.

This paper identifies a molecular marker for sex determination in Syrian hamster pups using placental tissues, achieving 85% specificity in sex classification.

PRSNet-2 predicts complex phenotypes from genotypic data using a hierarchical graph neural network, outperforming baselines and reducing overfitting.

The paper identifies trans-acting mutations in yeast that modulate gene expression noise in both intrinsic and extrinsic ways, revealing non-nuclear factors influencing nuclear gene expression.

This paper identifies β-nicotinamide mononucleotide (NMN) as a naturally occurring broad-spectrum CRISPR inhibitor that targets multiple Cas proteins, reducing off-target effects and improving safety in genome editing.

The paper identifies INS-17 as a specific insulin-receptor ligand in C. elegans that regulates learning and memory independently of lifespan.

CRISPR-All enables genome-scale, combinatorial genetic perturbations in human cells, revealing additive functional improvements through multiplexed modifications.

This study identifies osm-11's role in enhancing salinity stress tolerance in C. elegans by modulating fatty acid metabolism, cytochrome P450 pathways, and suppressing calcium signaling.

This study identifies how incomplete functional divergence of SEPALLATA MADS-box genes drives genetic synergy in tomato floral development through residual redundancy and non-additive expression.

The paper develops COMET, a method to infer clonal hematopoiesis from bulk DNA methylation data, showing it accurately detects clonal expansion and replicates known genetic associations.

The paper identifies an estrogen-mediated regulatory cascade involving PDLIM3, miR-9, miR-10, miR-6769b, and RUNX2 through ER/{beta} signaling, with implications for bone and tissue regeneration.

The paper models how genetic variation propagates across phenotypic levels using concave relationships to explain phenotypic buffering, dominance, heritability, and inbreeding depression.

PRISM improves polygenic score transferability across populations by integrating ancestry-aware tissue-specific genomic annotations, achieving a 13.10% performance boost for African ancestry.

This paper develops a non-viral genome-editing method called STEP-RNPs that effectively treats Angelman syndrome in mice and human neurons, showing functional genetic rescue without off-target effects.

This study shows RasG12V mutants amplify EGFR signaling, accelerating ERK activation but requiring EGFR for full pathway activation, suggesting combined inhibition of Ras and EGFR could improve therapy for RasG12V tumors.

The paper uses machine learning to identify common risk variants associated with ASD and links them to abnormal eye physiology.

This study evaluates two models, BayesS and [G], for detecting selection history in animal breeding, showing their effectiveness varies with heritability and data characteristics.

The paper validates epitope-tagged UAS-Ubiquitin transgenes in Drosophila to accurately recapitulate endogenous ubiquitination patterns at neuromuscular junctions.

This study establishes a Drosophila model of RVCL-S that recapitulates disease features, showing vascular deterioration and reduced lifespan in TREX1 mutant flies.

The paper analyzes metagenomes and MAGs from a wastewater treatment plant under varying DO conditions to study microbial adaptation to energy-efficient processes.

The paper investigates the genetic basis of twin and single spots in tobacco, finding that they arise primarily from deletions, translocations, and aneuploidy rather than homologous recombination.