Discover, rate, and discuss biology papers.

This study shows bleomycin causes centromere damage and chromatin mislocalization in fibroblasts, linking it to systemic sclerosis features.

The paper introduces an AI-enhanced marker-assisted selection approach for breeding honey bees with improved Vitellogenin (Vg) alleles to address colony loss challenges.

This study identifies a KPNA7 mutation causing otosclerosis by disrupting PTHrP nuclear transport and reactivating chondrogenesis in the otic capsule.

The paper introduces methods to detect neutral mutation disequilibrium (NMD) and applies them to Drosophila, mouse, and human genomes, finding NMD is common and may mislead evolutionary inferences.

The paper shows cold-induced liver exosomes containing miR-293-5p enhance brown adipose thermogenesis and reduce obesity in mice.

The paper investigates the protective role of the Stat5bY665F mutation in acute kidney injury using mouse models and transcriptomic analyses.

This study shows that CRISPR base editing can correct pathogenic PKD1 variants in mice, reducing liver cysts and increasing polycystin-1 expression.

Preclinical safety and efficacy studies of a new gene therapy approach for patients with severe β-hemoglobinopathies.

The paper identifies a regulatory variant driving microphthalmia by analyzing its effects in mouse models and linking it to FOXE3 expression and ocular development.

This study shows that DNA-binding-independent mechanisms contribute to dFOXO's role in metabolic regulation in Drosophila, as evidenced by altered lipid mobilization and transcriptional changes in metabolic and chromatin regulators during starvation.

The paper identifies ancestry-specific chromatin architecture differences in Alzheimer's Disease using Hi-C and ATAC-seq data from African and European ancestry individuals.

This paper shows that the PF gene explains only 22% of runnering variation in strawberries and demonstrates that genomic prediction for runnering is feasible.

This study identifies three factors that suppress meiotic crossovers near centromeres in Arabidopsis and shows that their mutation increases crossover frequency in these regions.

The paper shows ZNF93, a primate-specific protein, regulates APOBEC3B and influences cancer progression by affecting DNA synthesis and genomic stability.

This study identifies three downregulated genes in breast cancer lymph node metastasis and shows their fibroblast-specific roles in maintaining stromal barriers, with therapeutic implications.

This paper identifies key molecular drivers of breast cancer brain metastasis through multi-omics analysis and proposes therapeutic strategies based on gene and miRNA dysregulation.

This paper shows that early-stage sparse testing strategies increase genetic gain in plant breeding by improving selection accuracy and intensity through broader TPE sampling and reduced replication.

The paper introduces the Causal Pivot (CP) method to detect causal genetic variants in complex diseases using structural causal models and applies it to UK Biobank data for three diseases.

ERSAtool provides an intuitive R/Shiny interface for RNA-seq analysis, reducing technical barriers and supporting educational use with comprehensive reporting.

The paper shows that premature termination codons in Zfp423 cause different phenotypes in mice, challenging the assumption that all PTCs are functionally equivalent.