Discover, rate, and discuss biology preprints.

The paper annotates protein-coding genes in 301 Drosophilidae species and analyzes evolutionary patterns in gene number and codon usage.

The paper identifies distinct cochlear cell types associated with genetic susceptibility to sensory and metabolic hearing loss in older adults using integrated human and mouse data.

MitoDrift models mitochondrial inheritance to enable high-precision lineage tracing in human tissues, revealing clonal dynamics and linking them to transcriptional and epigenetic programs.

The paper presents the first haplotype-resolved genome assembly of lemongrass, providing a high-quality reference for genetic and metabolic studies.

The paper identifies H3K115ac enrichment at fragile nucleosomes in promoters and enhancers, suggesting its role in nucleosome destabilization and regulatory element identification.

The paper uses fully phased telomere-to-telomere assemblies and long-read epigenomes to study centromere genetic and epigenetic dynamics across inheritance and cell-fate transitions, finding positional stability of CDRs and dynamic epigenetic changes.

This paper reports the genome of Pavonine herpesvirus 1, a novel Mardivirus from peafowl, showing it lacks oncogenic genes found in Mareks disease virus.

This study uses eHiCA to identify regulatory interactions at the PICALM-EED locus, showing distinct chromatin interactions for SNPs within a segregating haplotype.

The paper develops a Flex-Seq SNP panel for red raspberry and validates it through linkage maps and QTL identification for agronomic traits.

MENDELSEEK predicts Mendelian genes using machine learning, achieving high accuracy and identifying novel candidates with precision over 0.7.

The paper introduces OneCell CUT&Tag, a single-cell multi-omics method that captures chromatin, transcriptome, and surface marker data, revealing epigenomic reprogramming during mammary gland basal-to-luminal transition.

The paper presents and analyzes the complete mitochondrial genome of the Madras hedgehog, providing insights into its evolutionary history and divergence within Erinaceidae.

The paper develops TiMEstamp to identify LINE-1 chimeric insertions in the human genome, revealing new chimeras and mechanisms like trans-splicing.

commonPeak identifies common ChIP-seq peaks across conditions and protocols using equivalence testing, finding 225 shared estrogen receptor peaks with similar enrichment in breast cancer cells.

This paper identifies RNA-binding proteins and regulatory networks in Leishmania parasites across multiple species and conditions, highlighting conserved and lineage-specific RBPs and their roles in life-stage, stress, and drug resistance.

The paper analyzes SARS-CoV-2-human protein-protein interactions to show Spike S may target cytoskeletal proteins via coiled-coil domains.

The paper identifies target genes and regulatory networks for bone mineral density GWAS loci using STING-seq, linking noncoding variants to gene function in osteoblasts.

This study identifies three conserved genomic regions in ants as evolutionary hotspots for venom genes, revealing repeated recruitment to conserved platforms and diverse evolutionary dynamics.

The paper identifies allele-specific alternative polyadenylation events in Alzheimer's disease brains and links them to genetic risk loci for neurodevelopmental and neurodegenerative disorders.

This study identifies eQTLs and environmental influences on immune cell diversity in Indonesian populations, highlighting the role of ancestry and environment in shaping immunity.