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The paper quantifies telomere content variation across 26 global human populations and finds significant differences between African-ancestry populations in the Americas and other superpopulations.

The paper traces the evolutionary impact of transposons on human inflammatory enhancers and shows their role in disease susceptibility through population genetics analysis.

The paper jointly profiles neuronal morphology and gene expression during iPSC differentiation to better understand neuronal development and disease modeling.

This study evaluates multiple MPRA and STARR-seq datasets to identify enhancers, finding inconsistencies due to technical factors and proposing a unified pipeline to improve cross-assay agreement.

This study generates genomic and epigenomic maps of mouse centromeres and pericentromeres using long-read sequencing and epigenetic analyses, revealing satellite DNA composition and chromatin state differences.

This study analyzes ancient DNA from Iron Age Saka pastoralists in Kyrgyzstan, revealing genetic patterns consistent with patrilocality and female-mediated genetic diversity.

This paper introduces end-to-end genomic prediction to directly predict images and text from genetic markers, showing comparable accuracy to traditional numeric phenotype-based methods.

This paper develops a pooled paired prime editing screen to generate large-scale deletions across the genome, identifying non-coding regions with fitness effects and demonstrating the feasibility of genome-wide deletion perturbation.

This study performs a multi-ancestry transcriptome-wide association study (TWAS) to identify shared and population-specific genetic effects in Alzheimer's disease using RNA-seq and genotype data from multiple cohorts.

The paper analyzes single-stranded DNA (ssDNA) formation in human and non-human ape telomere-to-telomere genomes to identify non-B DNA structures and their functional roles.

The paper presents a multi-tissue sheep atlas identifying regulatory variants and their effects on molecular phenotypes, revealing allelic heterogeneity and evolutionary patterns.

The paper identifies genetic modifiers of Hirschsprung disease severity using a mouse model and multiomic analysis of the Enteric Nervous System.

The paper uses whole-genome data from tinamous to reconstruct their phylogeny, estimate divergence times, and assess the impact of incomplete lineage sorting and introgression on genome evolution.

The paper presents a chromosome-level genome assembly for wild alpine reindeer and improves the assembly for Svalbard reindeer, providing gene annotations and comparisons with prior assemblies.

MERFISH+ enables high-resolution spatial multi-omics mapping of gene expression and chromatin organization in developing human hearts with subcellular resolution.

This study investigates Amoebic Gill Disease (AGD) in Atlantic salmon using a holo-omic approach, linking host genetics, microbiota, and disease resistance traits.

The paper identifies cryptic genetic diversity in Pacific herring, showing a biogeographic break linked to glacial cycles.

The paper presents a global virome atlas, UHGV, and identifies genomic factors influencing phage-host interactions.

This study uses nanopore long-read sequencing to analyze genomic disruptions in Alzheimer's disease, finding increased retrotransposon activity and structural variants in aged brains.

The paper benchmarks human read removal methods in metagenomics, finding that high-sensitivity Bowtie2 with T2T-CHM13 reference improves removal while preserving microbial data.