Discover, rate, and discuss biology preprints.

This paper introduces SCR, a Bayesian framework for estimating spatially-resolved gene co-expression networks to identify spatially co-expressed genes as potential biomarkers and therapeutic targets.

This study presents a haplotype-resolved genome of barberry and shows how haplotype divergence and allele-specific expression contribute to transcriptional responses during wheat stripe rust infection.

MissenseHMM annotates missense variants with states derived from joint modeling of pathogenicity scores, improving associations with clinical and experimental data.

The paper analyzes genome composition across vertebrates and invertebrates to show that CpG depletion defines a compositional axis, with AG/CT as its strongest marker, not the direct mutational product TpG/CpA.

This study identifies ellagic acid from Corynebacterium amycolatum SB-1 as a bioactive compound with anti-melanogenic and collagen-promoting effects on skin cells.

The paper introduces MILK, a framework for organizing single-cell genomic data into tree representations, enabling scalable analysis and preserving information across large datasets.

The paper demonstrates that mitotic chromosomes are mechanically connected by DNA-based interchromosome linkers, identified through micropipette manipulation and enzymatic treatments.

The paper analyzes genetic diversity and population structure of Lupinus perennis using genomic data and recommends non-local seed provenancing for restoration in pine barrens.

The paper introduces Centrolign, a tool for aligning centromeric regions, revealing mutation dynamics and enabling variant calling in human centromeres.

The paper constructs a chromosome-level genome for Haliotis iris and identifies an ancient regulatory axis and a multifunctional mantle involved in body asymmetry and melanogenesis.

This study benchmarks four commercial LR snRNA-seq workflows, finding 10x Genomics 3' and 5' to be the most balanced for isoform-resolved single-nucleus transcriptomics.

The paper assembles genomes of seven Lens species and identifies fragile chromosomes linked to pericentric inversions and centromere diversity.

This paper develops a cell-permeable anti-CRISPR protein (6xNLS-Acr) that efficiently inhibits Cas9 activity in human cells, enhancing genome-editing specificity.

This study shows that cfDNA can map telomere chromatin structure, revealing age-related and disease-specific changes in telomeric footprints and gene signatures.

This paper introduces SMC(k), a tunable approximation of the Coalescent with Recombination, showing it balances computational efficiency and accuracy in simulating Ancestral Recombination Graphs.

The paper identifies multiple CDV spillover events into Neotropical primates in Brazil and identifies residue 519 of the hemagglutinin protein as a candidate marker of adaptation to primates.

The paper introduces a new pangenome viewer for maize that integrates graph and linear genome visualization to enhance structural variation analysis and locus characterization.

The paper curates 49 experimental single-base substitution signatures from cancer genomes to link mutational processes to DNA damage mechanisms.

This study presents the first telomere-to-telomere genome of Manilkara zapota, revealing repeat-mediated genome evolution and epigenetic regulation of transposable elements.

ntSynt-viz sorts genomes and chromosomes by synteny, normalizes strands, and draws chromosome-painting ribbon plots easier to interpret than NGenomeSyn output for human and hoverfly genomes.