Discover, rate, and discuss biology preprints.

LACHESIS infers evolutionary trajectories of malignant transformation from whole-genome sequencing data and provides risk stratification for childhood and adult cancers.

This study identifies latent regulatory programs from disease-associated variants to reveal biological mechanisms and clinical subtypes in complex diseases.

This study shows Rift Valley fever virus lineage C circulates persistently in Rwanda through local transmission, not repeated introductions, based on whole-genome sequencing of livestock samples from 2022-2025.

The paper reports high prevalence of chloroquine resistance markers in Plasmodium falciparum parasites in Rwanda, 2018, with increasing resistance despite no drug pressure.

The paper catalogs mobile element insertions in 82 Indian populations, revealing population-specific variants not present in European databases and highlighting their potential impact on disease associations.

The paper evaluates nine methods for variable selection and prediction in high-dimensional ecological and evolutionary data, finding that overfitting is common but prediction accuracy improves with more observations and stronger effects.

This study presents a multi-omic atlas of the siphonophore Physalia utriculus, revealing the regulatory mechanisms of colonial division of labour and the molecular basis of venom activity.

The paper investigates mutation and recombination patterns in human acrocentric chromosome short arms using multiple sequencing technologies and a four-generation pedigree.

The paper creates a Pol III activity atlas across tissues and cancers, revealing context-specific expression patterns and linking them to subnuclear compartmentalization.

USER-excisable uracil TSOs, a uracil-intolerant polymerase and excess primer confine UMI incorporation to reverse transcription, minimizing background and UMI inflation; a separate Omega-shaped dT primer captures stranded transcript ends.

This study examines somatic mutation patterns in two cerebellar neuron types, finding similar substitution mutation rates but distinct insertion-deletion patterns influenced by transcription.

The paper identifies a large and diverse phospholipase gene cluster in Ceratocystis species, suggesting it contributes to pathogenicity and host range.

The paper generates a consensus genome sequence for Dictyostelium giganteum, analyzing its structure, gene content, and evolutionary relationships with other Dictyostelium and Entamoeba species.

The paper presents a population genomic resource for Drosophila pseudoobscura, analyzing 60 sequenced genomes to study chromosomal structure and genetic variation across the species' geographic range.

The paper uses GROVER to analyze how DNA sequence, chromatin, and regulatory features influence genome stability by predicting DSB locations and identifying sequence tokens associated with DSB sensitivity.

The paper presents a high-accuracy T2T rhesus macaque genome assembly, identifies subtelomeric repeats as a challenge, and reveals new genomic features and functional elements in these regions.

The paper analyzes carbohydrate degradation machineries in lichen fungal symbionts and finds distinct enzymatic patterns linked to different carbon subsidy types.

The paper presents whole genome sequences of two elasmobranchs, analyzing genome size dynamics and genomic architecture, revealing correlations between chromosome size, repetitive elements, and gene duplication patterns.

This paper presents the first fully phased, diploid, telomere-to-telomere genome of the zebra finch, revealing new genes and structural features.

Smooth muscle foam cells in early-to-intermediate human coronary plaques map to fibromyocytes, express CFH and SERPINE1 unlike macrophage foam cells, and show matrix, coagulation and angiogenesis programs.