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This study identifies pUS28 as a viral protein that inhibits CIITA-driven HLA-II expression, thereby blocking CD4+ T-cell recognition of HCMV-infected cells.

The paper uses single-cell RNA sequencing and flow cytometry to analyze myeloid cells in young and aged mouse ovaries, identifying aging-related changes in macrophage subsets and signaling pathways.

This study evaluates BECC adjuvants' ability to enhance HA-based influenza vaccine efficacy in mice, showing improved immune responses and viral clearance.

The paper examines how three common assumptions in stable isotope labelling studies affect interpretations of cell dynamics and proposes ways to reduce resulting errors.

This study shows that cGAS-STING-dependent type I IFN signaling is required for host defense against Leptospira interrogans in mice by reducing renal colonization.

The study shows that SARS-CoV-2 nucleocapsid protein persistence without viral replication leads to type I interferon production and mitochondrial dysfunction, promoting autoimmunity.

This study shows that PDE10A inhibition reduces lipid droplet formation and increases macrophage susceptibility to ferroptosis after LPS treatment.

This study shows that early-life colonization by Bacteroides fragilis in NOD mice accelerates type 1 diabetes progression by altering microbiota composition and immune responses.

This study shows ENaC is overexpressed in CF macrophages and contributes to their dysfunction, with ENaC inhibition improving immune function and reducing inflammation.

This paper develops an active soluble LIGHT protein that promotes immune cell infiltration and delays tumor growth in a melanoma model.

The paper shows that immune responses to AAV-mediated ocular gene delivery vary across species and individuals, complicating reliable immunomonitoring.

This study shows combining a RhCMV/SIV vaccine with neutralizing antibodies enhances protection against SIV challenge in rhesus macaques.

This paper reviews pre-clinical Schistosoma mansoni vaccine studies, finding that only two antigens achieved over 90% efficacy, but most vaccines fall short of required thresholds due to variable formulations and study designs.

This study shows that Plasmodium falciparum uses extracellular vesicles to deliver miR-451a to neutrophils, impairing their antimicrobial function and increasing susceptibility to bacterial superinfections.

This study identifies mechanical sensing via Piezo1 as critical for lung-specific neutrophils to maintain pulmonary homeostasis and respond to infection.

This study identifies PGAM as a negative regulator of Th17 pathogenicity using single-cell RNA-seq and metabolic flux analysis.

This study investigates ZIKV infection in fetal brain tissue, identifying astrocyte immune responses and neuronal dysfunction linked to congenital Zika syndrome.

This study uses a magnetic particle-based platform to mechanically modulate T-cell receptors, showing that NFAT pathway signaling accumulation is required for CD4+ T cell activation.

The paper identifies NKG7 as a reliable and consistent marker of cytotoxicity across immune subsets and tissues, outperforming traditional markers like Granzyme B and Perforin.