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This study uses spatial transcriptomics to compare HIV/SIV reservoirs with tumor microenvironments, identifying shared gene pathways and potential therapeutic targets.

This study identifies seven miRNAs upregulated in SARS-CoV-2 infected individuals, with some showing strong diagnostic accuracy, and links them to immune-related genes.

This study determines the structure of Bap1 bound to VPS and shows how it facilitates biofilm adhesion and VPS organization through a conserved β-propeller interaction.

The paper determines high-resolution structures of adenovirus particles at different proteolytic stages, revealing how protease-driven remodeling affects capsid stability and maturation.

This study shows that microbiome-mediated biotransformation of effera(R) enhances epithelial barrier function in an ex vivo model by increasing SCFA production and modulating inflammatory responses.

The study finds that higher human population density correlates with increased resistant E. coli isolation from seagulls.

This paper identifies a hierarchical regulatory cascade in Staphylococcus aureus that defines the temporal window for natural transformation by linking environmental and metabolic cues to gene expression.

This study compares transmission efficiency and infectious dose requirements of West Nile virus lineages 1 and 2 in different mosquito species.

This study identifies CtaA as a regulator of H2S production and virulence in S. aureus by linking metabolic reprogramming to redox defense under glucose-depleted conditions.

The paper identifies two small molecules, Amb929 and Amb701, as potent inhibitors of SARS-CoV-2 nsp3 and nsp5, with Amb929 showing higher antiviral activity and lower cytotoxicity.

This study identifies SpxA1 and SpxA2 as regulators of virulence gene expression in GAS, showing their stoichiometric balance determines transcriptional programs through interactions with CovR.

This study identifies endophytic bacteria from Cola nitida with larvicidal activity against insecticide-resistant Anopheles gambiae, showing minimal phytotoxicity and potential as biocontrol agents.

This study evaluates the in vitro synergistic effects of pibrentasvir combined with azole antifungal agents against several fungal pathogens.

The paper identifies a Type II RhlB helicase in Pseudomonas aeruginosa that forms toxic condensates, which are resolved by RNase E through antagonizing phase separation.

This paper develops a multivalent live-attenuated influenza vaccine that provides broad protection against multiple H5N1 clades by incorporating HA and NA from representative clades, showing robust immune responses and protection in mice.

This study shows that different Drosophila cell types impose distinct selective pressures on DCV replication and evolution, with mesodermal cells supporting higher viral replication than glial or S2 cells.

This study identifies a synergistic combination of nitrofurantoin and dequalinium that effectively treats antibiotic-resistant Klebsiella pneumoniae in UTIs by targeting bacterial metabolism.

The paper examines how two gut microbes interact under bile acid stress, finding that one species helps the other survive by exchanging vitamin B6.