Discover, rate, and discuss biology preprints.

This study shows that antigenic selection of influenza virus within hosts is driven by immune pressure timing and fitness tradeoffs, with moderate stochastic effects observed.

This study compares sugar utilization and metabolism in anaerobic gut fungi, revealing species-specific responses to co-substrates and highlighting functional diversity in carbon metabolism.

This study compares MALDI-TOF MS and whole-genome sequencing for identifying Vibrio parahaemolyticus strains from oysters, finding MALDI-TOF MS provides comparable resolution to WGS for strain tracking.

This study identifies metabolic reprogramming and immune signaling modulation by Vibrio parahaemolyticus during host cell invasion and infection.

The paper uses virus-driven proximity proteomics to identify p400 as a host restriction factor targeting incoming viral genomes during the immediate-early phase of infection.

The paper uses metabolomics to identify complex carbohydrate utilization in murine gut microbiota and develops a new medium to cultivate previously unculturable Firmicutes.

This paper designs and tests aminopeptidase-activated AMP prodrugs that selectively target Pseudomonas aeruginosa, showing improved antimicrobial activity and reduced cross-resistance.

The paper investigates the structural basis of endopilus assembly, stability, and functional specificity in bacterial type II secretion systems using comparative analysis of two pathogens.

The paper shows that promoters and terminators in bacteria are often coupled, with termination sequences contributing to promoter function, leading to regulatory interference between adjacent transcription units.

The paper shows that cell orientation patterning in Escherichia coli is linked to the spatial activation of the Rcs stress-response pathway, which is involved in extracellular matrix production and biofilm initiation.

This study examines fungal community assembly in Scandinavian lakes, finding low determinism and significant variability not explained by environmental factors or geographic distance.

This study compares thermotolerance, UV-C tolerance, and biofilm formation in R. mucilaginosa strains from different origins on medical plastics.

This paper introduces a self-regulating CRISPRi system that reduces leakiness while maintaining inducible gene repression, enabling portable and multiplexed applications.

This study uses machine learning to predict antimicrobial responses of Pleurotus ostreatus extracts against pathogens, finding extraction solvent as the strongest predictor but limited success in MIC classification.

This paper develops a feline calicivirus reporter virus to assess antibody neutralisation and antivirals, identifying GS-441524 as a potential therapeutic.

This paper shows that loss of YqeK in S. aureus increases stress sensitivity and reduces virulence gene expression, suggesting YqeK as a target for anti-virulence drugs.

This paper reports on a halotolerant marine Corynebacterium amycolatum strain that produces melanin with antimicrobial, antioxidant, and photoprotective properties, showing non-cytotoxicity in vitro and in vivo.

The paper shows that plant glucosinolates select for bacterial communities with redundant and cooperative metabolic functions in wild Arabidopsis leaves.

The paper uses metabolomics to show that HIV-treated individuals have metabolic disruptions, including lipid changes and inflammation markers, despite viral suppression.