Matthew D. Weitzman

The paper uses virus-driven proximity proteomics to identify p400 as a host restriction factor targeting incoming viral genomes during the immediate-early phase of infection.

This study shows adenovirus mutants differentially activate dsRNA sensors, leading to distinct RNP granule assemblies via PKR and OAS3/RNase L pathways.

This study shows HSV-1 uses RAD51 to enhance viral gene expression by binding to promoter regions and interacting with ADNP.

The paper identifies HR factors that inhibit dual AAV vector transduction and shows that inhibiting these factors improves transgene reconstitution.

This study identifies the SMC5/6 complex as essential for genome stability in cells with active APOBEC3A, showing that its loss leads to increased DNA damage and replication stress.

The paper uses direct RNA long-read sequencing to show m6A modifications on adenovirus RNA are necessary for efficient splicing.

This study shows that herpesvirus recombination occurs when replication compartments coalesce, revealing spatial and temporal requirements for inter-genomic recombination.