A Hypothalamic Pathway for Energy Conservation
Amelia Douglass, Nicole Lynch, Matías Andina…·Natalia Machado
This study identifies a hypothalamic pathway involving ARCAgRP neurons and the MnPO that triggers energy conservation during fasting.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Amelia Douglass, Nicole Lynch, Matías Andina…·Natalia Machado
This study identifies a hypothalamic pathway involving ARCAgRP neurons and the MnPO that triggers energy conservation during fasting.
Beatriu Molina-Esteve, Jose Manuel Crugeiras, María Rodríguez-Brañas…·Esther Udina
This study shows that early postnatal sensory neurons regenerate without upregulating regeneration-associated genes, suggesting distinct regenerative mechanisms compared to adult neurons.
Eissa Alfadil, Severin Filser, Benjamin Escribano…·Frank Bradke
This study identifies a low-adhesion mechanism driven by microtubule stabilization that enables rapid axon growth in the developing mouse brain.
Sudhuman Singh, Sunny Zhihong Jiang, William J. Fortun Rosado…·Yarimar Carrasquillo
The paper investigates the differential roles of PACAP and glutamate in parabrachial neurons in shaping pain and stress responses, showing distinct effects on injury-induced hypersensitivity and inflammation-induced pain.
Tingxin Zhang, Daniela Barbosa, Aksheev Bhambri, Lu O. Sun
This study identifies ER-phagy as a negative regulator of myelin sheath thickness by degrading sphingolipid synthases in oligodendrocytes, preventing excessive myelination.
Maike Renkert, Gilles de Hollander, Caroline Biegel…·Christian Carl Ruff
This study investigates dyscalculia by analyzing computational models of behavior and parietal cortex in adolescents, finding both domain-specific and domain-general deficits.
Laura Green, Shinya Ito, Darrell Haufler…·Anton Arkhipov
This study uses biologically realistic simulations to show that cortical circuit stability and information integration increase with hierarchy, linked to increased connectivity and SST cell proportion.
Julian Dominik Schulte, Jakub Vohryzek, Martí Monge-Asensio…·Gustavo Deco
This study links receptor profiles and cortical excitability to acute and long-term stroke outcomes using patient-specific whole-brain models.
Giovanna De Albuquerque Silva Braga, Penelope Pando, Hannah Hazzard…·Amanda C. Kentner
This study shows that milk-derived extracellular vesicles from enriched environments can rescue neuroimmune deficits in offspring following maternal immune activation.
Roberta Schellino, Federica La Rocca, Giulia Iezzi…·Alessandro Vercelli
This study identifies early maturation defects and selective degeneration of cortical projection neurons in a mouse model of SMA, highlighting cortical pathology beyond lower motor neurons.
Monica Hegde, Mohammadreza Edalati, Anne Kösem…·Sahar Moghimi
This study shows that synchronized rhythmic touch enhances and prolongs newborns' neural tracking of auditory rhythm beyond the period of tactile stimulation.
Ratna Mahathi Vuruputuri, Vaishnavi Reghunath, Shreyasi Mukherjee…·Vidita A. Vaidya
This study investigates the role of 5-HT2A receptors in the medial prefrontal cortex in DOI-induced head-twitch responses in rodents, finding no contribution from mPFC 5-HT2ARs.
James Chilton Thompson, Courtney Marsh, Peter Kakalec…·Rebecca Van Roy
This study shows that stimulating the right posterior superior temporal sulcus (rpSTS) disrupts shared neural responses to social content during movie watching, suggesting its role in encoding common social information.
Lilianne Barbar, Anushka Bhat, Si Jia Chen…·Aaron DiAntonio
This study shows that enhancing mitochondrial NAD+ import through SLC25A51 protects neurons from SARM1-driven degeneration by preventing coupled metabolic failure.
Samuel A. Neymotin, Hananel Hazan, Gözde Ünal…·David L. Boothe
This paper introduces evidence-gated plasticity (EGP) and its target-context extension to improve multi-goal learning in spiking neural networks, showing enhanced reward acquisition and target-contact success.
Muskan Khetan, Ye Ella Tian, Nandita Vijayakumar…·Sarah Whittle
This study examines how monthly variability in oestradiol and progesterone in adolescent females relates to brain structure and mental health outcomes.
Rubi Ruopp, Emily A. Williams, Mary Gach…·Ian Greenhouse
This study investigates motor automaticity in keyboard typing by analyzing sequence frequency and performance metrics in natural and pseudo-word strings.
Annie Park, Bhagyashree Senapati, Nino Mancini…·Scott Waddell
This paper shows how hunger reconfigures a reward circuit in Drosophila to support memory formation by switching dopamine neuron activity modes.
Roya Sharifpour, Sophie Elands, Jeromy Hrabovecky…·Mélanie Strauss
This study investigates glymphatic function in MS using MRI and finds that gBOLD-CSF coupling correlates with sleep, disability, and structural changes, while DTI-ALPS shows limited utility due to microstructural confounding.
Taylor Nakayama, Dario X. Figueroa Velez, Whitney England…·Sunil Gandhi