Discover, rate, and discuss biology preprints.

This study creates 3D spatial models of human liver tissue to identify new morphometric parameters and topological defects linked to NAFLD progression.

The paper trains a convolutional neural network to classify white blood cells with human-level accuracy, enabling efficient detection of blast cells in acute myeloid leukemia.

This paper develops a deep learning framework to segment glomeruli in trichrome-stained kidney biopsy images, achieving high accuracy in distinguishing glomerular regions.

This study examines C4d deposition in renal tissues of primary Sjögren's syndrome patients, finding higher serum creatinine levels in those with tubulointerstitial C4d positivity.

This paper introduces Digital Spatial Profiling (DSP), a method for high-plex spatial analysis of proteins and RNA in tissue, and demonstrates its application in studying immune and cancer microenvironments.

This study shows that pressure overload in ApoE-/- mice leads to coronary plaque formation, progression, and myocardial events, mimicking human coronary artery disease.

This study finds that over 50% of histologically normal endometrium samples contain somatic driver mutations, including KRAS, PIK3CA, FGFR2, and PTEN loss, with prevalence increasing with age.

This paper uses deep learning to classify Renal Cell Carcinoma subtypes and predict patient survival from histopathology images, achieving high accuracy and identifying survival-associated morphological features.

This study tracks ocular changes in Fabry disease patients over time, finding that enzyme replacement therapy does not prevent progression of several eye conditions.

This study compares corneal biomechanics between patients with ocular graft-versus-host disease and healthy controls, finding reduced corneal hysteresis and resistance factor in oGVHD patients, with correlations between biomechanical parameters and disease severity and MMP-9 levels.

This study identifies metabolic biomarkers of premature aging in HGPS patients through metabolomic profiling and multivariate analysis.

This study investigates retinal lesion formation in mice following prolonged ocular exposure during anesthesia recovery, finding that unprotected eyes in open chambers develop significant lesions, while protected eyes show no complications.

This study shows that allergic inflammation in mice reduces severity of viral-bacterial co-infection by altering the lung microbiome and immune response.

This study identifies virus-related genes associated with stunted growth in juvenile Pacific White Shrimp through transcriptome analysis.

The paper investigates proinsulin processing abnormalities in T1D islets, finding reduced processing enzymes and cytokine-induced expression changes.

This study examines the effects of high iodine contrast agent Visipaque on thyroid function tests and sonography in euthyroid patients, finding no significant changes in thyroid function but increased urine iodine concentration and thyroid volume in the treated group.

This study develops LAMP assays for detecting FOE in oil palm seedlings but finds they cannot distinguish FOE from presumed-FOE and non-FOE isolates.

The study evaluates the upgrade rate of radial scar/complex sclerosing lesion with atypia to malignancy on surgical excision, finding higher rates with atypical ductal hyperplasia than lobular neoplasia.

This study uses hPSC-derived 3D lung organoids to model fibrotic lung disease, identifying IL-11 as a potential therapeutic target for IPF and HPSIP.

This study identifies a proteolytic cleavage mechanism in INF2 that affects its function in podocytes, leading to impaired localization and contributing to FSGS.