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This study characterizes RPE structure and lipid changes in a ZSD mouse model, identifying lipid alterations that precede and accompany retinal degeneration.

The paper identifies Aqp1 as critical for lacteal maintenance and inflammatory lymphatic remodelling through single-cell RNA-sequencing and genetic studies in mice.

This paper introduces Adaptive Example Selection (AES), an XAI framework for mitosis detection that enhances model interpretability by comparing test cases with annotated prototypes.

This study shows LRP2 levels are reduced in non-syndromic high myopia and posterior staphyloma, and its expression is modulated by light and cortisol.

This study predicts West Nile Virus risk across Europe using species distribution modeling, showing increased risk in some areas and decreased risk in others under future climate scenarios.

The study evaluates host plants preferred by Asian citrus psyllid, finding curry leaf plant most effective for attracting the pest, with lower nymphal mortality compared to other hosts.

This study shows that REEP6 deficiency causes retinal degeneration by reducing phototransduction proteins due to ER and Golgi dysfunction and inflammation.

This paper develops a multimodal transformer model using H&E images and text reports to predict recurrence scores in hormone receptor-positive breast cancer, achieving high accuracy and generalizability.

In 415 European and Mediterranean wheat powdery mildew genomes, fungicide-resistance mutations rose over time with regional patterns; demethylation-inhibitor resistance at cyp51 emerged at least twice independently and spread.

This study shows that TCV's coat protein suppresses RNA decay by degrading AtDcp1 via ubiquitination and autophagy, enhancing viral infection.

This study tracks cardiac changes in DE50-MD dogs with DMD, showing worsening fibrosis and function decline over time, validated by CMR and histopathology.

This study identifies metabolic impairments and oxidative stress in Prpf31 mutant mouse RPE cells as key factors in retinitis pigmentosa pathogenesis.

This study uses a zebrafish model to show mycobacteria cause transient vascular occlusions and ischemia during early brain infection, establishing a model for TBM vascular complications.

This paper introduces VQ-MIL, a weakly supervised vector quantization method for WSI classification, achieving state-of-the-art results on benchmark datasets.

This study shows melatonin alleviates lysosomal damage in diabetic kidney disease by upregulating TFEB and the miR-205-5p-LRP-1 pathway, improving autophagy and oxidative stress.

This paper investigates the link between low choline levels, obesity, metabolic dysfunction, and neuropathology in humans and 3xTg-AD mice, finding sex-specific and obesity-related associations.

This study uses spatial transcriptomics to compare gene expression in intima and media of human coronary arteries, revealing dedifferentiated SMCs in DIT that differ from proinflammatory SMCs in atherosclerotic lesions.

This study shows a small-molecule agonist of KIF2C enhances DNA repair and mitigates aging phenotypes in progeria and Down syndrome models.

This study evaluates the immunopharmacological efficacy of Leishmania donovani overexpressing Ld_ζ1domain as a vaccine candidate against visceral leishmaniasis, showing reduced parasite burden and enhanced immune response.

This study shows SCFAs promote angiogenesis in PAD by activating FFAR3, while Palmitate impairs it, and FFAR3 loss blocks SCFA benefits.