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This study examines primary osteoarthritis in aged UM-HET3 mice, finding sex-specific effects of MB and MitoQ treatments and correlations between cartilage scores and inflammation, cell cycle markers, and subchondral bone changes.

This study shows that estrogen loss in female mdx mice reduces exercise capacity and mitochondrial metabolism, but estrogen replacement therapy can reverse these effects and upregulate Rbm20.

This study compares structural and gene expression changes in spleens of visceral leishmaniasis patients with and without HIV coinfection, identifying key pathways and gene associations linked to spleen disorganization.

This study finds that patients with Achilles tendinopathy exhibit reduced intra-tendinous sliding during plantarflexion compared to controls, with increased sliding observed in a toes-out foot position.

The paper examines islet and acinar cell secretion in different pancreatic regions across diabetes stages, finding reduced insulin secretion and beta-cell volume in T1D with normal enzyme secretion.

This study identifies three infarct growth phenotypes in ischemic stroke patients based on MRI data and shows they predict 3-month clinical outcomes.

This study uses scRNA-seq to analyze granulomatous lymph nodes from TB patients, identifying cell types, signaling networks, and Mtb RNA detection in infected cells.

This study evaluates the feasibility of en bloc kidney-ureter-bladder transplantation in pigs, finding successful urine flow and tissue preservation with no anastomotic leaks.

The paper uses an oxygen sensor-mounted biopsy tool to measure oxygen levels in human cancer xenografts in mice, providing additional diagnostic information through pO2 readings.

This study shows that UBE2N is crucial for skin homeostasis and inflammation suppression, with its loss causing inflammatory skin defects and identifying IRAK1/4 as a therapeutic target.

The paper uses Digital Spatial Profiling to analyze transcript localization in renal transplant biopsies, showing compartmentalized immune responses and persistent podocyte transcript reduction during antibody-mediated rejection.

This study compares lobular geometry and CYP450 zonation across four species using whole slide imaging, identifying species differences and determining the minimum number of lobules needed for statistical analysis.

This study shows that blocking Kynurenine monooxygenase (KMO) reduces endometriosis-like lesions, alleviates pain, and improves behavior in a mouse model of endometriosis.

This study evaluates the male ovine mammary gland microenvironment, comparing intact and neutered males, and demonstrates its utility as a model for male breast biology.

This study characterizes the Ts66Yah murine model of Down syndrome, revealing genotype-related molecular changes in hippocampal pathways linked to aging and cognitive decline.

This study examines neuropathological changes in the olfactory bulb and tract of COVID-19 patients, finding no significant inflammation but age-related decline in anti-CD68 reactivity and mild increases in phospho-Syn and phospho-tau signals in affected brains.

The study examines how genetic diversity in aphid populations affects the transmission efficiency of barley yellow dwarf virus, finding significant variation in R. padi but not S. avenae.

This study shows that Cbfβ deficiency leads to OA by altering Wnt/β-catenin, Hippo/Yap, and TGFβ signaling, and that local Cbfβ overexpression protects against OA in mice.

This study identifies a transcriptomic signature and secreted factors from Gs-activated BMSCs in fibrous dysplasia, linking them to pro-inflammatory and pro-osteoclastic behavior and potential therapeutic targets.

This study identifies hemato-chemical parameter changes in hog deer infected with Theileria, Babesia, and Anaplasma to develop diagnostic tools for early detection of these parasites.