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SCOPE improves AI triage in 3D pathology by using morphology-aware prototypes to identify high-risk 2D slices for pathologist review.

This study introduces spatial-GPT, a platform for spatial glycan, protein, and transcriptome profiling in human liver tissues, revealing glyco-codes that define disease states and progression.

This study shows that ERK overactivation contributes to endothelial cell hyperproliferation in HHT, suggesting ERK inhibition as a potential therapy.

SCALE3D improves prostate cancer risk prediction by analyzing 3D cell interactions through supercell graphs, outperforming traditional features and reducing computational demands.

This study identifies Menacanthus stamineus as the causative louse species in Bangladesh's battery-caged layer farms and documents its negative impacts on bird health and productivity.

This study uses human liver organoids to model Wolman disease, showing multicellular interactions drive disease features and therapeutic responses.

This study identifies CD8+TOX+ T-cells as a specific marker for autoimmune hepatitis using single-nucleus RNA sequencing.

This study shows PFOS worsens atherosclerosis by expanding Bacteroides caecimuris, altering bile acids, and activating FXR-TLR3 signaling in the gut.

This study compares histopathological features of three diabetic kidney disease models, finding that Akita and STZ models show clear structural changes while db/db models require electron microscopy for accurate assessment.

This study shows that platelet GARP activates TGF-β1 to limit inflammation and promote cardiac repair after myocardial infarction.

This study shows that loss of HIF1α in smooth muscle cells in atherosclerosis leads to oxidative stress, increased SMC proliferation, and plaque expansion.

This study shows that Eed deficiency in hepatocytes causes liver injury, fibrosis, and altered regeneration by disrupting H3K27me3 regulation of pro-regenerative genes.

This study investigates TWEAK and Fn14 expression in human osteoarthritis cartilage and finds TWEAK induces RANKL release from chondrocytes.

The paper introduces a modular AI framework for ROI selection in spatial profiling, showing hybrid generalist-specialist strategies balance signal preservation, concordance, consistency, and efficiency.

This study identifies TGM2-mediated histone serotonylation as a cardioprotective epigenetic mechanism in HFpEF, showing its role in stress response and cardiac function.

This paper establishes a CD4-negative cell line model for studying HIV-1 infection and latent viral reservoirs, showing that CD4-negative cells can be infected and support both productive and latent infection.

This paper evaluates if H&E WSIs from TCGA-OV can predict HRD status using label refinement and foundation models, finding modest predictive performance but limited clinical interpretability.

This study shows that reducing NR4A3 levels improves MASLD by suppressing ATF3 activity, reducing liver fat, inflammation, and insulin resistance.

This study identifies two transcription factors in Bursaphelenchus xylophilus that non-redundantly regulate gene expression across its life cycle, with distinct roles in parasitism and reproduction.