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This study uses single-nucleus RNA-seq and spatial transcriptomics to identify lineage-specific regulatory changes and candidate therapeutic targets in hypertrophy cardiomyopathy.

This paper develops a convolutional neural network to screen body fluid cytology smears for malignant cells, achieving high sensitivity and specificity but with room for improvement in detecting scattered cells and reducing false positives.

This paper develops a transgenic zebrafish reporter to measure proteinuria, demonstrating its utility in detecting kidney disease models and drug responses.

This study shows that OPN deficiency reduces inflammation and fibrosis in the prostate after E. coli infection in mice.

This study identifies BcPTP1 as a phytotoxic effector secreted by Botrytis cinerea during late infection, which induces cell death and promotes lesion spreading.

This meta-analysis finds that OCD patients show longer stop-signal reaction times, indicating impaired response inhibition, with greater deficits in older individuals.

TaBln1 negatively regulates wheat resistance to stripe rust by reducing Ca2+ influx through its interaction with TaCaM3 on the plasma membrane.

The paper examines the rational use of plant protection products in a vineyard to manage fungal diseases while minimizing environmental and health risks.

This study shows that Phyllanthus niruri extract reduces malaria parasite numbers by blocking erythrocyte invasion and modulates host immune responses, protecting against cerebral malaria in mice.

The paper develops a model to classify invasive ductal carcinoma on whole slide images using transfer learning and weakly-supervised learning, achieving ROC AUCs of 0.95-0.98 on test sets.

The paper classifies decidual vasculopathy into types, finding atherosis of trophoblast type is distinct and linked to lower placental weight but not specific clinical features.

A progressive context encoder trained only on normal skin whole slide images flags melanoma regions without manual tumor labels, reaching 89% pixel-level accuracy across 9 test slides.

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

This study shows that Nintedanib prevents cardiac fibrosis and dysfunction in a mouse model of heart failure, even after treatment interruption.

This study examines 2D and 3D vascular and white matter changes in CADASIL, HTRA1-AD, and sSVD using light-sheet fluorescence microscopy, revealing distinct patterns of degeneration.

This study assesses batch effects in TMA-based cancer biomarker studies and shows mitigation methods reduce variance and alter clinical associations.

This study identifies multiple triggering factors for mutation repair in RNA viruses and shows that cell-to-cell movement enhances mutation repair, opposing the Muller ratchet effect.

This study tracks clinical and physiological changes in kra monkeys infected with P. knowlesi, revealing mechanisms of resilience to malaria.

This study investigates lipid metabolism changes in soybean cultivars resistant and susceptible to Phytophthora sojae, identifying lipid biomarkers that may aid in developing plant protection strategies.