Discover, rate, and discuss biology preprints.

This study uses a novel deep proteomic approach to analyze aging and resistance training effects on skeletal muscle proteomes, revealing distinct molecular changes in myofibrillar and non-myofibrillar fractions.

The paper identifies a new class of secreted mammalian peptides, capped peptides, which may regulate cell-cell communication through post-translational modifications.

This study shows that IGF-1 supplementation improves kidney development and reduces inflammation in preterm pigs.

This study develops a PET-based method to track nitrogen gas movement in vivo and ex vivo using 13N2, showing its distribution in organs after inhalation.

The paper calculates equivalent slopes for running effort under different wind conditions and analyzes physiological corrections and speed adjustments.

This study shows that cold exposure induces spreading depolarization in butterfly brains, leading to loss of central nervous system function and supporting its role in the critical thermal minimum across insects.

This study identifies key factors driving variability in human subcutaneous adipose tissue, including VEGFA, ACTA2, adipocyte density, and patient ancestry.

This study identifies Atg8-LC3's role in leptin secretion across species, linking autophagy proteins to nutrient surplus signaling and organismal resilience.

This study investigates how chronic intermittent hypoxia and high-fat diet affect liver metabolism, showing that hypoxia worsens lipid deposition and mitochondrial dysfunction in obese rats.

The paper models thermal sensitivity of diapause development in apple maggot flies, showing that incorporating individual and ontogenetic variation improves predictions of emergence timing.

This study shows heat stress disrupts acid-base homeostasis in the sea anemone Exaiptasia diaphana regardless of symbiont presence, indicating climate change impacts beyond bleaching.

This study shows that foveal RGCs in primates develop altered calcium dynamics weeks after photoreceptor loss, with a significant decrease in calcium decay constant.

This study investigates age and sex differences in mitochondrial substrate utilization during muscle contraction, finding that aged muscle shows altered fatty acid oxidation and metabolic responses to different exercise protocols.

This study shows MFGE8 inhibits insulin signaling by promoting PTP1B binding to and dephosphorylation of IR{beta}, reducing glucose uptake, and identifies a correlation between serum MFGE8 levels and insulin resistance in humans.

This study shows 17α-estradiol improves metabolic and inflammatory outcomes in skeletal muscle of male mice but not females on a high-fat diet.

The paper shows that combining chloride and calcium channel dysfunction in mice worsens myotonic dystrophy symptoms, and calcium blockers can improve survival and function.

This study identifies the purinergic P2Y2 receptor as a mediator of lung ischemia-reperfusion injury by activating endothelial TRPV4 channels through extracellular ATP release via Panx1.

This study develops a computational model of renal electrolyte transport in rats to analyze sex differences in calcium and sodium handling and responses to pharmacological interventions.

This study investigates the effects of repeated methamphetamine exposure on zebrafish cardiac function, revealing decreased heart rate, increased heart rate variability, and fibrotic changes.