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This study shows that knocking down Rbp1, a fly spliceosome component, extends lifespan regardless of when the treatment is initiated.

The paper identifies a catecholamine-independent lipolysis pathway activated by hypoglycemia and hypoinsulinemia that enables catabolism of stable adipose tissues.

This study identifies differences in the secretome of neonatal mesenchymal stem cells from mothers with obesity compared to normal-weight mothers, showing altered redox capacity and adipogenic signaling.

This study shows that elevated dietary cholesterol in rats leads to liver lipid crystals, which increase tissue stiffness and fibrosis progression in a model of MASLD.

This study shows that transient hypoxia followed by reoxygenation is essential for skeletal muscle repair, mediated by Rev-ERBalpha regulation of myogenesis.

This study examines how different squat loads affect jump performance in female basketball players, finding that 80% of 1RM with 8-12 min recovery optimally enhances performance.

This study identifies cellular and molecular changes in human hip sub-synovial adipose tissue linked to osteoarthritis and aging, highlighting increased stem cells, immune alterations, and gene expression patterns.

This study shows that restoring leptin signaling in adipocytes of obese male mice improves BAT thermogenesis, glycemic control, and cardiovascular health, but not in females.

This study examines atrial t-tubule development in sheep, showing that despite reduced density in newborns, Ca2+ handling is maintained through increased L-type Ca2+ current and sarcoplasmic reticulum content.

This study identifies urea carbon salvage as a mechanism enabling hibernating squirrels to reuse urea and mucins for energy during fasting.

This study tracks the metabolic fate of sugars and amino acids during flight in butterflies, showing how flight intensity affects nutrient allocation between flight and reproduction.

This study shows that female spontaneously hypertensive rats develop diet-dependent coronary microvascular dysfunction, which can serve as a model for hypertension-related CMD.

This study shows dietary tryptophan improves AhR activation and reduces colitis by enhancing microbial tryptophan metabolism in preclinical models.

This study uses a microfluidic platform to link red blood cell properties to whole-blood rheology in sickle cell disease, revealing how stiff cell proportions and spatial organization drive pathological flow resistance.

This paper develops a microphysiological system using hiPSC-derived neurons and cardiomyocytes to model sympathetic neuro-cardiac interactions and test drug effects.

This study shows that ovulation is essential for female sexual receptivity in medaka, and progesterone signaling in specific brain regions synchronizes sexual behavior with the ovulatory cycle.

The paper develops and applies transvaginal ovum retrieval techniques in scimitar horned oryx and roan antelope to support assisted reproductive technologies for conservation.

This study shows that Δ133p53 reduces CXCL10 levels in progeria and aged mice, linking it to anti-inflammatory effects.

This study shows that high PVC burden causes inflammation and fibrosis, leading to adverse cardiac remodeling and increased risk of heart failure and sudden cardiac death.

This paper develops a hybrid machine learning and musculoskeletal simulation framework to improve dynamics estimation from smartphone video during walking, achieving lower error rates than simulation-only or ML-only approaches.