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The frequency of menstrual cycles with a suboptimal decidual reaction determines the recurrence risk of miscarriage.

TGFβ2 raises TRPV4 expression and activity in human trabecular meshwork cells; TRPV4 blockade or deletion lowers TGFβ2-driven ocular hypertension and contractility in mice and hydrogels.

This study tests if cone photoreceptors affect melatonin suppression and alertness to light at night, finding no significant effect.

This study examines age-related changes in serial sarcomere number across five hindlimb muscles in rats at four aging timepoints, finding significant SSN loss contributing to muscle mass decline.

This paper develops a high-resolution kinematic method to quantify impaired mobility in dystrophic zebrafish larvae, finding significant differences in swimming performance between mutants and wild-types.

This study identifies G-quadruplex stabilization as the mechanism by which resveratrol exerts its multi-target pharmacological effects.

This study knocks down mTOR in trophoblasts of late pregnant mice, reducing placental nutrient transport and fetal growth.

This study shows dietary fiber reduces TMAO formation after beef consumption, particularly in low meat eaters, by downregulating cutC expression.

This study shows early-life exercise training can mitigate low inborn cardiorespiratory fitness effects, but molecular adaptations vary based on innate fitness.

This study shows that Gata4 downregulation in the hypothalamus of Greywick female mice models the metabolic subtype of PCOS by affecting fertility and food intake genes.

The paper shows that resting calcium fluxes prevent mitochondrial fragmentation and transcriptional changes in astrocytes by modulating ER stress and gene expression.

This study shows that reducing CPT1a in the liver lowers apoB-containing lipoproteins and cholesterol in mice, with increased clearance of these lipoproteins linked to enhanced PPAR signaling.

The paper introduces an optoretinographic imaging platform to measure human retinal neuron responses to diverse stimuli and proposes a model to predict these responses.

This study examines how variations in chronic variable stress procedures affect behavioral outcomes in mice, finding that longer and more diverse stress regimens reduce effect sizes in certain tests.

This study shows that diet-induced obesity paradoxically increases SERCA activity in atrial myocytes, contributing to atrial fibrillation through altered Ca2+ dynamics.

This study shows that topical L-menthol reduces voluntary wheel running in mice but still allows exercise to improve metabolic health by increasing energy expenditure.

This study identifies Allatotropin and sNPF neuropeptide signalings as regulators of post-mating refractory behavior and male reproductive system function in Gryllus bimaculatus.

This study compares the effects of aerobic exercise and dietary restriction on liver senescence in mice with diet-induced MASLD, finding that dietary restriction is more effective than exercise alone.

This study shows that early-life exposure to high omega-6 fatty acids impairs adipocyte mitochondrial oxidation by suppressing NR2F2, which can be reversed by reactivating NR2F2 in stem-like cells.