Gregory A. Graf

ABCG5 ABCG8-independent mechanisms fail to maintain sterol balance in mice fed a high cholesterol diet

This study shows that G5G8-independent mechanisms cannot compensate for G5G8 deficiency in mice fed a high cholesterol diet, leading to sterol accumulation in the liver and plasma.

Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers Apolipoprotein B Containing Lipoproteins in Mice

This study shows that reducing CPT1a in the liver lowers apoB-containing lipoproteins and cholesterol in mice, with increased clearance of these lipoproteins linked to enhanced PPAR signaling.

Functional Exploration of Conserved Sequences in the Distal Face of Angiotensinogen

This study investigates the functional role of conserved sequences in the loop and β-sheet regions of angiotensinogen, showing that mutations in either region individually have no effect, but combined mutations impair AGT secretion.

Bioinformatic analysis of endogenous and exogenous small RNAs on lipoproteins

The paper introduces TIGER, a pipeline for analyzing extracellular small RNAs, demonstrating its ability to identify sRNAs on lipoproteins and in biofluids with high accuracy.