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This paper develops a multiscale computational model to predict skeletal muscle hypertrophy by integrating mechanical and biochemical stimuli, showing how exercise protocols affect muscle growth and shape.

This study shows that loss of GRPEL2 in mice protects against age- and diet-induced obesity and improves metabolic health without affecting mitochondrial protein import.

This study shows that hair cell function declines with age in mice before hearing loss is detectable, challenging the idea that stereocilia are the most fragile part of sensory cells in aging.

This study identifies oral microbiome-derived VOCs as confounders in breath analysis by showing glucose-induced changes in exhaled acetoin, acetic acid, and ethanol levels.

This study compares mitochondrial function in anterior and posterior gills of shore crabs, finding distinct phenotypes linked to their specialized roles in respiration and osmoregulation.

This paper introduces a non-invasive method to measure oral-cecal transit time in mice by tracking microbial oxidation of 13C-mannitol to 13CO2 using spectroscopy and calorimetry.

This study shows that acute exposure to cell-free mitochondrial DNA in pregnant rats causes aortic endothelial dysfunction and organ-specific inflammation, with partial TLR9 involvement.

This study examines how obesity and sarcopenia alter metabolite profiles in dogs, finding increased inflammation and lipid metabolism disruptions in overweight dogs and modest metabolic effects in those with reduced muscle mass.

This study shows that gene therapy with AAV-ALPK3 improves heart function in mouse and human models of cardiomyopathy caused by ALPK3 variants.

This study shows that FAM210A deficiency in hepatocytes causes juvenile mitochondrial dysfunction and steatosis, which resolves in adulthood through compensatory mechanisms.

This study describes the maintenance of selectively bred obesity-prone and obesity-resistant rat lines, characterizes their phenotypes, and examines striatal function and food motivation.

This paper shows that myeloid cell recruitment drives right ventricular dysfunction in HFpEF through sterile inflammation in both mice and humans.

This study investigates how ER calcium depletion triggers structural changes in STIM1 that enable CAD release and Orai1 channel activation through single-molecule FRET experiments.

This paper uses polarized second-harmonic generation microscopy to analyze myosin states in hypertrophic cardiomyopathy, showing increased ON state fraction in mutated tissue.

This study shows that Ffar4 in cardiac myocytes reduces systolic dysfunction after ischemia-reperfusion by improving mitochondrial function and cGMP signaling.

This study investigates how dietary iron affects bacterial infections in Manduca sexta larvae, finding that increased iron does not enhance infection severity but has context-dependent effects on survival.

This study identifies Orai1 as a regulator of Ca2+ entry in brown adipocytes, linking it to lipolysis, mitochondrial activation, and thermogenesis during cold exposure.

This study compares kinematics and muscle activity during half squats and gait between individuals with a history of ankle sprain (copers) and healthy controls, finding differences in thigh movement and muscle activation during squats.

This study maps the molecular landscape of hypertension using single-cell data from multiple organs and models, linking genetic variants to disease mechanisms.

This study uses Hill-type muscle modeling to predict optimal parameters for maximizing average mechanical power output during stretch-shortening cycles in rat medial gastrocnemius muscle.