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This study examines how different exercise intensities affect the human plasma secretome and interorgan communication through multi-cohort interventions and multi-organ gene expression analysis.

This study examines lipidomic changes in Phaeodactylum tricornutum under low temperature and darkness, revealing distinct adaptations in plastid and endomembrane lipids.

This study evaluates the impact of coated essential amino acid supplementation on the growth and digestibility of plant-based diets for rainbow trout, finding improved performance with coated forms.

The paper identifies an inflammatory secretory progenitor cell state in Crohn's disease patients and shows its epigenetic regulation in stem cells.

The paper identifies elastic tissue motion as a general motor skill indicator by comparing experts and non-experts using ultrasound and deep learning.

This study develops a novel indirect calorimetry method to quantify metabolic fluxes in human macrophages and reveals distinct metabolic signatures between M(LPS+INF-γ) and M(IL-4) subsets.

The paper develops a mathematical framework explaining circadian intraocular pressure (IOP) rhythms through the additive interaction of glucocorticoid and norepinephrine signals, showing it accounts for species differences and age-related changes.

This study standardizes the mouse MCAO stroke model by distinguishing ICA and PPA occlusion, showing 15-minute ICA occlusion balances infarction and survival best.

This study shows that the gut microbiome increases mitochondrial respiration and oxidative stress in the brain of a Parkinson's disease mouse model, worsening motor symptoms.

This study uses synchrotron micro-CT to quantify microstructural changes in CLL marrow, finding reduced lacuna density and increased adipose surface area linked to disease burden and therapy response.

This study compares cardiac structure and function in free-ranging and captive rhesus macaques across age, finding that captive macaques show more pronounced age-related cardiac changes.

This study shows ADAMTS13 deficiency worsens ulcerative colitis by promoting microthrombi formation, mucosal damage, and endothelial dysfunction, with intravital imaging revealing these mechanisms at single-cell resolution.

This study identifies increased TGFβ/Activin-Smad2 signaling in GDM as a contributor to β-cell dysfunction and glucose intolerance, with pharmacological inhibition showing therapeutic potential.

This study investigates the effects of beta-hydroxybutyrate (BHB) supplementation in DMD disease models, showing reduced muscle damage and improved muscle function without adverse effects.

This study shows hypoalbuminemia reduces fibrin clot porosity and impairs fibrinolysis in nephrotic syndrome, suggesting albumin directly enhances fibrinolysis.

This study investigates correlations between exercise hyperemia and muscle energetics in the human upper arm using MRI and MR spectroscopy, finding inverse correlations between hyperemic slope and acidification.

This study examines how manipulating the source-sink ratio in rapeseed during grain filling affects yield, grain weight, and quality traits under different radiation conditions.

This study identifies marginal zone B cells as antigen-responsive subsets that amplify immune responses in hypertension through clonal expansion and intercellular communication with CD8+ T cells.