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This study develops a transgene self-elimination system in tobacco using CRISPR/Cas9 and BARNASE cassettes to generate transgene-free edited progeny through de novo regeneration.

This paper compares measurement-aware models and selection-level repairs in Bayesian optimisation for living-cell experiments, finding that measurement-aware models reduce regret and improve coverage under data contamination.

Single-cell eQTL mapping in 5.4 million PBMCs from 1,925 individuals with matched WGS finds common-variant eQTLs for 83% and rare-variant signals for 47% of 21,404 genes.

This study identifies RIPK1 activation as a key determinant of response to SMAC mimetics in TNBC, showing that resistance is linked to impaired RIPK1 autophosphorylation and HOIP overexpression.

This study examines the early molecular and metabolic responses of tomato plants to compost-derived bacteria, identifying common and strain-specific physiological signatures.

This study constructs a pangenome of Cryptococcus neoformans, revealing subtelomeres as hotspots for gene content variation and suggesting horizontal gene transfer.

This study evaluates the accuracy of mobile laser scanning for tree volume estimation, finding that tree shape has a limited impact on measurement error compared to scanning conditions and forest structure.

This paper uses information-theoretic methods to analyze tsetse fly antenna responses to odors, finding that trichoid sensilla carry more odor identity information than basiconic sensilla.

This review analyzes 20 years of salmonid research through early-career researchers' contributions, identifying trends, gaps, and future directions in the field.

The paper identifies two regulatory elements in Lte1 that coordinate kinase activity to compartmentalize Lte1 at the bud cortex in S. cerevisiae, ensuring proper mitotic exit.

This study identifies a functional interaction between the HIF-1 hypoxia response pathway and the NMD RNA surveillance pathway in C. elegans, showing NMD enhances specific aspects of the HIF-1 response.

This study profiles circulating hematopoietic stem and progenitor cells in MPN patients, identifying transcriptional signatures and quantitative readouts to distinguish MF from other MPNs and predict progression.

This study shows that loss of either SUR1 or Kir6.2 subunits in neurons increases dorsal root ganglion excitability and reduces morphine antinociception in mice.

This study identifies senescent cancer-associated fibroblasts (senCAFs) driven by MK2 that promote immunosuppression in bone metastases and shows that combining MK2 inhibition with OX40 agonists enhances immunotherapy efficacy.

The paper shows that oxidized TRX1 and DPP8/9 stabilize the MIA40-AIFM1 complex during intrinsic apoptosis, promoting NLRP1 restraint and preventing pyroptosis.

The paper introduces the SAR11 Genome Atlas, a resource integrating SAR11 genomes and functional data to support ecological and genomic analysis of oceanic bacteria.

This paper introduces Bayesian in situ PSF modeling to improve 3D nanoscopy in deep tissue by accounting for optical distortions and uncertainties in PSF estimation.

This study shows that plasmid-plasmid interactions alter EV cargo composition and gene transfer potential in microbial communities.

This study identifies T cell-derived IFNγ as a driver of ECM stiffening in HFpEF via LOXL3 in cardiac fibroblasts, showing therapeutic potential for targeting this pathway.

This study uses single-nucleus RNA-sequencing and multiome data to identify neuronal mitochondrial gene suppression as a driver of Alzheimer's dementia, revealing genetic and epigenetic mechanisms underlying cognitive resilience.