Howard Robert Horvitz

The nonsense-mediated decay RNA-surveillance pathway facilitates the hypoxia response by C. elegans

This study identifies a functional interaction between the HIF-1 hypoxia response pathway and the NMD RNA surveillance pathway in C. elegans, showing NMD enhances specific aspects of the HIF-1 response.

Cohesin and NuRD Antagonistically Drive Alternative Neuronal Fates via PLZF Transcription Factors

The paper shows cohesin and NuRD complexes antagonistically drive alternative neuronal fates via PLZF transcription factors in C. elegans.

Single-cell analyses reveal tissue-specific contextualization 1 of HIF-1 activity

The paper uses single-cell analysis to show that HIF-1 activity leads to shared and context-specific transcriptional responses across different tissues and cell types in C. elegans.

A DEAD-box helicase drives the partitioning of a pro-differentiation NAB protein into nuclear foci

The paper identifies a DEAD-box helicase that regulates the condensation of a NAB protein, influencing stem cell fate and cell differentiation in C. elegans.

Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior

The paper shows that blocking programmed cell death in C. elegans leads to extra neurons that alter specific behaviors like reversal frequency and duration.

Deletion of VPS50 protein in mice brain impairs synaptic function and behavior

This study shows that deleting VPS50 in mice brains impairs synaptic function and behavior by disrupting V-ATPase pump localization and vesicle acidification.

The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in C. elegans

This study identifies CTBP-1 and EGL-13 as critical for maintaining AIA interneuron identity in C. elegans by repressing transcriptional activity.

An Hourglass Circuit Motif Transforms a Motor Program via Subcellularly Localized Muscle Calcium Signaling and Contraction

The paper shows that subcellular muscle contraction in C. elegans enables modulatory motor control through an hourglass circuit motif.

Activity-dependent regulation of the proapoptotic BH3-only gene egl-1 in a living neuron pair in C. elegans

The paper shows that egl-1, a BH3-only gene in C. elegans, is transcriptionally regulated by neuronal activity and kinases in adult sensory neurons without inducing apoptosis.

Neurohormonal signalling controls insulin sensitivity and specificity in C. elegans

The paper investigates how neurohormonal signalling via SSU-1 regulates insulin sensitivity and specificity in C. elegans under different environmental stresses.