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This study identifies stromal COL12A1 as a key component of the extracellular matrix niche that supports invasion in appendiceal mucinous neoplasms and pseudomyxoma peritonei.

This paper demonstrates the directed evolution of a multimodal plastic-degrading enzyme capable of breaking down both polyesters and polyurethane.

This study develops a model explaining how nanometre-scale changes in receptor dimensions affect CAR-T cell antigen sensitivity by linking physical principles to experimental observations.

This study identifies evolutionary constraints linking Zika virus NS5 replication and interferon antagonism by analyzing fitness landscapes and attenuation in mice.

The paper introduces a numerical method to accurately model random genetic drift with or without natural selection and mutation, showing improved accuracy over standard methods.

The paper presents the first curated genome-scale metabolic model for L. rhamnosus GG, validated using multiple approaches and provides insights into its nutrient requirements and secretions.

This paper develops a collagen-based 3D microtissue model of ovarian cancer that preserves structural, molecular, and therapeutic heterogeneity across different histotypes.

This study shows that DegQ and SwrA have opposing effects on DegU-dependent phenotypes in Bacillus subtilis through distinct mechanisms.

This study shows DNA-PK enforces the S/G2 checkpoint in ATM-deficient cells, reducing ATR inhibitor efficacy, and suggests combining ATR and DNA-PK inhibition could enhance treatment in such cancers.

The paper identifies transient isoform remodeling as a key mechanism in early MAPKi resistance in melanoma, showing it is distinct from gene expression changes and linked to splicing regulators and developmental pathways.

This study uses longitudinal scRNA-seq to track neuroendocrine transdifferentiation in a prostate cancer model, identifying transcriptional changes and key regulators during treatment-induced NEPC progression.

This study investigates how changes in task relevance during redundant motor tasks distinguish between adaptation and structure learning mechanisms in monkeys.

This paper simulates protein evolution using programmable fitness objectives derived from modern protein models, showing that combined objectives improve evolutionary realism and molecular plausibility.

This study identifies regulators that control ECA biosynthesis in E. coli, showing ECA's role in acid and reactive nitrogen species stress resistance.

This study evaluates an H5 mRNA-LNP vaccine in lactating dairy cows, finding it reduces viral replication and disease in mammary glands.

The paper shows that spatial tactile cues improve motor accuracy and stability during sensory conflict by enhancing visuosomatosensory integration.

This study compares the metabolic and neuroendocrine effects of sleeve gastrectomy (SG) and gastric plication (GP) in obese mice, finding distinct outcomes despite similar weight loss.

TransPepMS verifies peptides not in reference proteomes by resolving ambiguities in mass-spectrometry data to distinguish genuine non-canonical peptides from false positives.

This study identifies genetic determinants of Brevundimonas-mediated attenuation of plant pattern-triggered immunity, finding TonB1 as the key factor.

This study demonstrates growing macroscopic functional human tissues on 3D-printed peptide hydrogels, enabling centimeter-scale neural organoids and directional axonal communication.