Rearrangement of chromosome spatial organization in mouse zygotes using optical tweezers does not affect preimplantation development
Corentin Mollier, Ozan Kastas, Laure de Chancel…·Jean‐Léon Maître
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Corentin Mollier, Ozan Kastas, Laure de Chancel…·Jean‐Léon Maître
Márcia Gonçalves Dias, Jacqueline Monaghan
This study identifies and characterizes FvCPK28, a strawberry ortholog of Arabidopsis CPK28, showing it retains similar biochemical and biological functions.
Dingwei He, Yuan Gao, Tom A. Rapoport
The paper reports the structure of a peroxisomal import channel and shows how it adapts to transport proteins of different sizes.
Jeff Y. Chen, Kevin Y. Zhang, Wilfred A. van der Donk
The paper investigates the mechanism of peptide modifications by DybH and ChrH enzymes, identifying key steps in macrocyclization and heterocycle formation through mutational analysis.
Agneesh Barua, Giulia Campli, Marcela Herrera Sarrias…·Marc Robinson‐Rechavi
This study identifies a conserved post-embryonic gene network in teleost fish that is responsive to thyroid hormone and ecological variation, showing how it evolves through gene copy number changes.
Roman Makitrynskyy, Imen Nouioui, Marlen Jando…·Yvonne Mast
This study identifies naphthocyclinones as antibiotics produced by Streptomyces hederae in wild bee nests, mediating bacterial competition and showing potential against Paenibacillus larvae.
Kelvin M. Ongaki, Elizabeth W. Wanderi, Sharon F. Akaranga…·Frank Onderi Masese
The paper examines phytoplankton beta diversity in Kenyan waterpans across seasons and land use, finding that genus replacement and weak spatial structure drive diversity patterns, with nutrient levels and cyanobacteria playing key roles in the dry season.
Xiaobo Sun, Yan Liang, Jinghua Hu
The paper identifies novel ciliary microtubule-associated proteins using BioID proximity labeling and proteomics, expanding the known repertoire of ciliary MAPs.
Rajyashree Sen, Lorenzo Posani, Alexander Medoff…·Stefano Fusi
The paper identifies a novel neural code in the mouse medial frontal cortex that supports spatial generalization through extrapolation of coordinates across regions.
Francesco Polazzo, Til Hämmig, Paula Eileen Stoeckli…·Owen L. Petchey
The paper shows that community performance curves predict temporal stability of ecological communities despite species interactions.
Sarah Youssef, Lauren Anderson, Mengyao Zheng, Arun Richard Chandrasekaran
This study shows that adding hairpins to DNA tetrahedra increases their nuclease resistance, enhancing biostability through sequence-specific stabilization.
Ramnarayan Bera, Swati Sharma, Deep Nath…·Soumen Roy
The paper uses discrete-time quantum walks to predict critical residues in proteins involved in long-range interactions, validated experimentally on AsLOV2.
Kevan P. Clifford, Thomas D. Prévot, Akiko Sumitomo…·Yuliya S. Nikolova
This study links the FREM3 gene to brain and cognitive aging using cross-species evidence from mice and humans, showing reduced brain volume and cognitive performance in Frem3 knockout mice and lower FREM3-GReX associated with reduced brain surface area and cognitive performance in humans.
Chul‐Woo Pyo, Wyatt C. Nelson, Ruihan Wang…·Daniel E. Geraghty
The paper provides high-resolution HLA and MICA/MICB typing for the 1000 Genomes panel, identifying population-specific variants and demonstrating the utility of HLA data for predicting MIC genotypes.
Mohd Ilyas, Ruchi Tomar, Prabhakar Babele…·Krishnamohan Atmakuri
This study uses BONCAT and conventional proteomics to identify infection-associated secreted proteins of Acinetobacter baumannii in A549 cells, revealing 152 proteins not detected in axenic cultures.
YeongNam Bae, Jinheon Baek, Eugene Choi…·Byung‐Ha Oh
This paper introduces K-Fold, a method that improves prediction of conformational changes in protein complexes by modeling structural transitions from unbound to bound states.
Malvina Marku, Cécile Pineau, Miguel Hurtado…·Mélanie White‐Koning
This paper develops a multiscale framework linking pharmacokinetics and Boolean models to study ibrutinib resistance in CLL, identifying key regulons and synergistic targets.
Christian Ayala-Ortiz, Peter A. Birschbach, Josué A. Rodríguez-Ramos…·Emily B. Graham
The paper examines how urbanization affects dissolved organic matter and microbial networks in a freshwater estuary by analyzing seasonal and spatial gradients.
Matilde Balbi, Stefano Regis, Giovanni Fiorito…·Enrico Cappelli
This study shows that the FA recipient environment after HCT causes metabolic, redox, and epigenetic changes in donor-derived hematopoietic cells, even when donor chimerism is stable.
Lea Klepka, Hannes Wallstein, Sascha Liepelt…·Anna Bucharová
This study shows that restored plant populations of Galium wirtgenii adapted to earlier mowing by flowering earlier, indicating a heritable evolutionary response.