Discover, rate, and discuss biology preprints.

The paper develops spatially-resolved models of the yeast galactose switch to show how intracellular organization affects regulatory dynamics.

The paper develops an analytical framework for reaction diffusion equations in Ca nanodomains, showing that Ca bound buffers and sensors propagate as traveling waves, supported by experimental measurements.

This study shows AI-2 functions as both a quorum sensing and metabolic signal in E. coli, linking nutrient sensing to population-level signaling through CRP and the lsr operon.

This study shows that electrical stimulation of the human pulvinar can generate visual percepts and alter cortical activity in patients with epilepsy.

The paper assesses how environmental and demographic factors influence feeding behavior of endangered long-tailed gorals at winter supplementary feeding stations.

The paper imputes fluid intelligence scores in a large cohort, reducing ascertainment bias and increasing power to detect genetic associations with common and rare variants.

This study shows rhesus monkeys can categorize facial expressions and generalize to novel stimuli, with performance influenced by expression components and signaler characteristics.

This study uses Force Profile Analysis to examine the cotranslational folding of Firefly luciferase, revealing a complex, quasi-continuous folding process with multiple intermediate steps.

This paper introduces BINOCULAR, a system for rapid, multiplexed detection of Mycoplasma using toehold switch sensors, achieving sub-5-minute readout times and 1-copy/µL sensitivity.

DCSE predicts drug combination side effects using a deep learning model, outperforming existing methods in realistic settings with limited data.

This study evaluates the short-term impact of ULV insecticide spraying on mosquito and non-target insect populations in Hungary using a BACI design, finding significant reductions in both but highlighting ecological trade-offs.

This paper predicts recovery trajectories and injury severity after partial crush spinal cord injury in mice using behavioral data and statistical modeling.

This study evaluates Bovine AAV as a vector for pulmonary gene therapy, showing efficient lung transduction and reduced neutralization compared to conventional AAV serotypes.

This study examines how immunosuppressive drugs affect glucose-stimulated insulin secretion using dynamic perifusion assays, finding concentration-dependent inhibition with varying patterns among drug types.

The paper shows that fear learning reorganizes brain activity, and this reorganization predicts extinction memory expression when modulated by TMS during extinction learning.

This study shows that darker pupal coloration in butterflies increases desiccation tolerance, suggesting pupal color plasticity serves an adaptive role in reducing water loss.

This study shows loratadine reduces MRSA virulence by targeting hemolysin regulators vraSR and agr, decreasing alpha and beta hemolysis in vitro and in cell models.

This study shows Bacillus subtilis biofilms use polymer composition to drive gel formation and morphological transitions through swelling and cross-linking.

This study identifies L-CK1.2 interacting partners in Leishmania and host macrophages, revealing its dual role in parasite survival and host immune processes.

This study compares oral and gut microbiomes in HIV patients and finds oral bacteria like Veillonella parvula contribute to systemic inflammation through epithelial barrier disruption and monocyte activation.