Nicolas C Näpflin

This study shows AI-2 functions as both a quorum sensing and metabolic signal in E. coli, linking nutrient sensing to population-level signaling through CRP and the lsr operon.

The paper evaluates WISH-barcoding in Salmonella Typhimurium for in vivo population dynamics, finding wild-type strains prone to fitness-altering mutations during in vitro construction.

This study identifies D-gluconate as a key nutrient source for Salmonella during both acute and chronic infection, supporting its growth in the inflamed gut.

MicrobeAtlas unifies over two million microbiome samples to enable cross-technology insights into microbial ecosystems and their global patterns.

This paper uses large language models to automate the annotation of microbiome sequencing records, achieving better performance than a keyword-based approach.

The paper analyzes the pan-genome of nearly 20,000 Enterobacteriaceae genomes to identify core and accessory metabolic genes, revealing core genes for mixed acid fermentation and accessory genes for anaerobic respiration and carbohydrate utilization.

This study identifies context-dependent and -independent carbohydrates used by Salmonella Typhimurium for gut colonization in mice, highlighting D-glucose, D-fructose, and D-galactose as key substrates.