Author

K. L. Asfahl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 4 Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. A. Dandekar· 4 shared N. E. Smalley· 3 shared A. Crabbe· 1 shared A. L. Schaefer· 1 shared A. P. Chang· 1 shared C. Fonseca Garcia· 1 shared C. Gauthier· 1 shared C. Majerczyk· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersMicrobiology

A. A. Dandekar

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Author profile →

5 papers

Recent·Most cited

Umbrella toxin particles produced by Streptomyces block mycelial growth of competing species

Q. Zhao, S. Bertolli, Y.-J. Park, Y. Tan, K. J. Cutler, P. Srinivas, K. L. Asfahl, C. Fonseca Garcia, L. A. Gallagher, Y. Li, Y. Wang, D. Coleman-Derr, F. DiMaio, D. Zhang, S. B. Peterson, , J. D. Mougous

This study identifies umbrella toxin particles produced by Streptomyces that inhibit the growth of competing bacterial species, distinct from small molecule antibiotics.

bioRxiv · Dec 9, 2023 · PreprintMicrobiology

Genetic and transcriptomic characteristics of RhlR-dependent quorum sensing in cystic fibrosis isolates of Pseudomonas aeruginosa

K. L. Asfahl, N. E. Smalley, A. P. Chang, A. A. Dandekar

The paper examines genetic and transcriptomic features of RhlR-dependent quorum sensing in Pseudomonas aeruginosa isolates from cystic fibrosis patients, identifying a core regulon and highlighting the importance of RhlR in chronic infections.

bioRxiv · Dec 21, 2021Microbiology

Evolution of the quorum sensing regulon in cooperating populations of Pseudomonas aeruginosa

N. E. Smalley, A. L. Schaefer, K. L. Asfahl, C. Perez, E. P. Greenberg, A. A. Dandekar

The paper shows that long-term growth of Pseudomonas aeruginosa under limited QS conditions reduces the number of QS-activated genes by 45-70%.

bioRxiv · Jul 1, 2021Microbiology

Burkholderia thailandensis methylated hydroxy-alkylquinolines: biosynthesis and antimicrobial activity in co-culture experiments

J. R. Klaus, C. Majerczyk, S. Moon, N. A. Eppler, S. Smith, E. Tuma, M.-C. Groleau, K. L. Asfahl, N. E. Smalley, H. Hayden, M. Piochon, P. Ball, A. A. Dandekar, C. Gauthier, E. Deziel, J. R. Chandler

This study identifies N-oxidated methyl-alkenylquinolines (HMAQ-NOs) as antimicrobial compounds produced by Burkholderia thailandensis, showing they are 50-fold more active than their non-oxidized counterparts against Bacillus subtilis.

bioRxiv · May 27, 2020Microbiology

Non-hierarchical, RhlR-regulated acyl-homoserine lactone quorum sensing in a cystic fibrosis isolate of Pseudomonas aeruginosa

R. L. Cruz, K. L. Asfahl, S. Van den Bossche, T. Coenye, A. Crabbe, A. A. Dandekar

The paper shows that a LasR-null Pseudomonas aeruginosa isolate uses RhlR for quorum sensing and virulence, suggesting RhlR as a therapeutic target in chronic infections.

bioRxiv · Sep 2, 2019Microbiology