E. Deziel

Temperature-responsive control of Pseudomonas aeruginosa virulence determinants through the stabilization of quorum sensing transcriptional regulator RhlR

This study shows that lower temperatures increase RhlR activity in Pseudomonas aeruginosa through enhanced stability of the RhlR/C4-HSL/PqsE complex, affecting virulence factor expression.

Inhibition of PQS signaling by the Pf bacteriophage protein PfsE enhances viral replication in Pseudomonas aeruginosa

The paper identifies PfsE as a Pf phage protein that inhibits PQS quorum sensing and type IV pili extension, enhancing viral replication and protecting the host from competing phages.

Surface growth of Pseudomonas aeruginosa reveals a regulatory effect of 3-oxo-C12-homoserine lactone in absence of its cognate receptor, LasR

This paper shows that Pseudomonas aeruginosa produces 3-oxo-C12-HSL without LasR during surface growth, upregulating virulence factors in neighboring cells.

Adaptive radioresistance of Enterohemorrhagic Escherichia coli O157:H7 results in genomic loss of shiga toxin-encoding prophages

This study shows that adaptive resistance of EHEC O157:H7 to gamma-irradiation involves loss of prophages encoding shiga toxins and mutations in specific genes, leading to reduced virulence and increased radioresistance.

Emergence of Small Colony Variants (SCVs) is an adaptive strategy used by Pseudomonas aeruginosa to palliate O2 limitations

This study identifies O2 limitations as the main factor promoting the emergence of Small Colony Variants (SCVs) in Pseudomonas aeruginosa, which helps the bacterium survive by forming biofilms to access electron acceptors.

Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system

This study develops a polymicrobial biofilm model of the CF lung to investigate community-specific antimicrobial resistance and identifies LasR loss-of-function as a driver of tobramycin tolerance through increased phenazine production.

Pseudomonas aeruginosa strains from both clinical and environmental origins readily adopt a stable small colony variant (SCV) phenotype resulting from single mutations in c-di-GMP pathways

Tackling Recalcitrant Pseudomonas aeruginosa Infections In Critical Illness via Anti-virulence Monotherapy

This study identifies novel anti-MvfR compounds (NAMs) that reduce intestinal permeability and inflammation in Pseudomonas aeruginosa infections, offering a potential monotherapy for critical illness.

Surface motility favors co-dependent interaction between Pseudomonas aeruginosa and Burkholderia cenocepacia

The paper shows that Pseudomonas aeruginosa provides rhamnolipids enabling Burkholderia cenocepacia to swarm, and aflagellated PA14 allows both to colonize surfaces together.

Toxoflavin secreted by Pseudomonas alcaliphila inhibits growth of Legionella pneumophila and its host Vermamoeba vermiformis

This study identifies Pseudomonas alcaliphila as a potential inhibitor of Legionella pneumophila growth through toxoflavin production, which also affects its host Vermamoeba vermiformis.

Pseudomonas aeruginosa isolates defective in function of the LasR quorum sensing regulator are frequent in diverse environmental niches

The study identifies frequent LasR-defective Pseudomonas aeruginosa isolates in diverse environments, suggesting a widespread adaptation mechanism.

The ability of Pseudomonas aeruginosa to adopt a Small Colony Variant (SCV) phenotype is conserved, and not restricted to clinical isolates

This study shows that Pseudomonas aeruginosa strains from non-clinical environments can adopt a SCV-like phenotype under lab conditions, suggesting this ability is conserved across strains.

The bacterial virulence factors rhamnolipids and their (R)-3-hydroxyalkanoate precursors activate Arabidopsis innate immunity through two independent mechanisms

This paper shows that rhamnolipids and their (R)-3-hydroxyalkanoate precursors activate Arabidopsis immunity through two distinct mechanisms involving different receptors and signaling pathways.

Presence of the Hmq system and production of 4-hydroxy-3-methyl-2-alkylquinolines is heterogeneously distributed between Burkholderia cepacia complex species and more prevalent among environmental than clinical isolates

The paper investigates the distribution of the Hmq system and HMAQ production in Burkholderia cepacia complex strains, finding it more common in environmental isolates and species associated with plant roots.

An experimentally evolved variant of RsmA confirms its central role in the control of Pseudomonas aeruginosa social motility

This study uses experimental evolution to identify mutations in gacA and rsmA that rescue a swarming defect in a Pseudomonas aeruginosa mutant, confirming RsmA's central role in social motility.

Burkholderia thailandensis methylated hydroxy-alkylquinolines: biosynthesis and antimicrobial activity in co-culture experiments

This study identifies N-oxidated methyl-alkenylquinolines (HMAQ-NOs) as antimicrobial compounds produced by Burkholderia thailandensis, showing they are 50-fold more active than their non-oxidized counterparts against Bacillus subtilis.

ScmR, a global regulator of gene expression, quorum sensing, pH homeostasis, and virulence in Burkholderia thailandensis

Phenylacetyl-CoA, not phenylacetic acid, attenuates CepIR-regulated virulence in Burkholderia 2 cenocepacia

The paper shows that phenylacetyl-CoA, not phenylacetic acid, suppresses virulence in Burkholderia cenocepacia by indirectly affecting CepIR-regulated pathways.

Polyhydroxyalkanoate granule accumulation makes optical density measurement an unreliable method for bacterial growth assessment in Burkholderia thailandensis

This study shows that optical density measurements are unreliable for assessing bacterial growth in Burkholderia thailandensis due to PHA granule accumulation affecting light scattering.

The symbiotic complex of Dendroctonus simplex: implications in the beetle attack and its life cycle

The paper investigates the bacterial and fungal microbiota of Dendroctonus simplex across its life stages using high-throughput sequencing, revealing a successional microbial assemblage linked to its symbiotic relationship with microorganisms.

Two rsaM homologues encode central regulatory elements modulating quorum sensing expression in Burkholderia thailandensis

This study identifies two rsaM homologues in Burkholderia thailandensis that regulate quorum sensing systems by repressing specific AHL biosynthesis pathways.