P. T. Toth

Impaired Barrier Integrity of the Skeletal Muscle Vascular Endothelium Drives Progression of Cancer Cachexia

This study identifies impaired vascular endothelial integrity in skeletal muscle as a driver of cancer cachexia and shows that restoring endothelial PGC1 can prevent muscle loss.

Matrimeres are systemic nanoscale mediators of tissue integrity and function

The paper identifies matrimeres as nanoscale mediators of tissue integrity, showing they can restore vascular integrity after injury and are reconstituted from fibronectin, DNA, and acidic conditions.

Parallel Activation of Src and Hif1α Increases Localized Glycolytic ATP Generation for Re-assembly of Endothelial Adherens Junctions

This study shows that Src and Hif1α activation increases glycolytic ATP production near endothelial adherens junctions, facilitating their re-assembly after injury.

Endosomal Trafficking of Two Pore K+ Efflux Channel TWIK2 to Plasmalemma Mediates NLRP3 Inflammasome Activation and Inflammatory Injury

This study shows that TWIK2 channels are trafficked from endosomes to the plasma membrane via Rab11a in response to ATP, leading to K+ efflux and NLRP3 inflammasome activation, which can be inhibited to reduce inflammation.

Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses

This study identifies endothelial mitophagy as a source of mitochondrial formyl proteins that activate neutrophils and contribute to lung inflammation.

Computer-Vision Stabilized Intravital Imaging Reveals Lung Capillary Neutrophil Dynamics Crucial for Lung Host-Defense Function

This study uses CASTii to analyze lung capillary neutrophil dynamics, revealing their role in host defense and response to infection.

EphB1 in Endothelial Cells Regulates Caveolae Formation and Endocytosis

This study shows that EphB1 in endothelial cells regulates caveolae formation and endocytosis by interacting with caveolin-1 and modulating Src-dependent phosphorylation.